1AQU
ESTROGEN SULFOTRANSFERASE WITH BOUND INACTIVE COFACTOR PAP AND 17-BETA ESTRADIOL
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004062 | molecular_function | aryl sulfotransferase activity |
| A | 0004304 | molecular_function | estrone sulfotransferase activity |
| A | 0005496 | molecular_function | steroid binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006068 | biological_process | ethanol catabolic process |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006711 | biological_process | estrogen catabolic process |
| A | 0007565 | biological_process | female pregnancy |
| A | 0008146 | molecular_function | sulfotransferase activity |
| A | 0008210 | biological_process | estrogen metabolic process |
| A | 0008289 | molecular_function | lipid binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0045600 | biological_process | positive regulation of fat cell differentiation |
| A | 0047894 | molecular_function | flavonol 3-sulfotransferase activity |
| A | 0050294 | molecular_function | steroid sulfotransferase activity |
| A | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| A | 0051923 | biological_process | sulfation |
| B | 0004062 | molecular_function | aryl sulfotransferase activity |
| B | 0004304 | molecular_function | estrone sulfotransferase activity |
| B | 0005496 | molecular_function | steroid binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006068 | biological_process | ethanol catabolic process |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006711 | biological_process | estrogen catabolic process |
| B | 0007565 | biological_process | female pregnancy |
| B | 0008146 | molecular_function | sulfotransferase activity |
| B | 0008210 | biological_process | estrogen metabolic process |
| B | 0008289 | molecular_function | lipid binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0045600 | biological_process | positive regulation of fat cell differentiation |
| B | 0047894 | molecular_function | flavonol 3-sulfotransferase activity |
| B | 0050294 | molecular_function | steroid sulfotransferase activity |
| B | 0050427 | biological_process | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| B | 0051923 | biological_process | sulfation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE A3P A 301 |
| Chain | Residue |
| A | LYS48 |
| A | THR227 |
| A | SER228 |
| A | PHE229 |
| A | MET232 |
| A | PHE255 |
| A | MET256 |
| A | ARG257 |
| A | LYS258 |
| A | GLY259 |
| A | HOH316 |
| A | SER49 |
| A | HOH366 |
| A | HOH367 |
| A | HOH368 |
| A | HOH395 |
| A | HOH396 |
| A | GLY50 |
| A | THR51 |
| A | THR52 |
| A | TRP53 |
| A | ARG130 |
| A | SER138 |
| A | TYR193 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE A3P B 302 |
| Chain | Residue |
| B | LYS48 |
| B | SER49 |
| B | GLY50 |
| B | THR51 |
| B | THR52 |
| B | TRP53 |
| B | ARG130 |
| B | SER138 |
| B | TYR193 |
| B | THR227 |
| B | SER228 |
| B | PHE229 |
| B | MET232 |
| B | PHE255 |
| B | MET256 |
| B | ARG257 |
| B | LYS258 |
| B | GLY259 |
| B | HOH316 |
| B | HOH324 |
| B | HOH374 |
| B | HOH385 |
| B | HOH387 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EST B 303 |
| Chain | Residue |
| B | ARG23 |
| B | TYR81 |
| B | CYS84 |
| B | ASN86 |
| B | LYS106 |
| B | HIS108 |
| B | PHE142 |
| B | TYR149 |
| B | MET247 |
| B | HOH385 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EST A 304 |
| Chain | Residue |
| A | ARG23 |
| A | TYR81 |
| A | CYS84 |
| A | ASN86 |
| A | LYS106 |
| A | HIS108 |
| A | PHE142 |
| A | TYR149 |
| A | MET247 |
| B | GLU246 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"9765259","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9360604","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9765259","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1AQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BO6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9360604","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AQU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P52844","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
