1APF
ANTHOPLEURIN-B, NMR, 20 STRUCTURES
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0009966 | biological_process | regulation of signal transduction |
| A | 0017080 | molecular_function | sodium channel regulator activity |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042151 | cellular_component | nematocyst |
| A | 0090729 | molecular_function | toxin activity |
| A | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 37 |
| Details | Region: {"description":"Well-structured region","evidences":[{"source":"PubMed","id":"14661964","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15170345","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Region: {"description":"Arg-14 loop (non-well-structured region)","evidences":[{"source":"PubMed","id":"14661964","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15170345","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Structurally important","evidences":[{"source":"PubMed","id":"8639500","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for sodium channel affinity and for toxin structure","evidences":[{"source":"PubMed","id":"8639500","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for affinity to sodium channel, probably due to the flexibility this residue gives to the Arg-14 loop","evidences":[{"source":"PubMed","id":"14661964","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Key residue for binding both cardiac and neuronal sodium channels","evidences":[{"source":"PubMed","id":"8276803","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for sodium channel affinity","evidences":[{"source":"PubMed","id":"8916901","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Site: {"description":"Not essential for sodium channel affinity","evidences":[{"source":"PubMed","id":"8288644","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Site: {"description":"Binds to sodium channel","evidences":[{"source":"PubMed","id":"15170345","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Site: {"description":"Has its side chain oriented away from the channel in the binary complex","evidences":[{"source":"PubMed","id":"15170345","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for high affinity to sodium channel","evidences":[{"source":"PubMed","id":"8621610","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Site: {"description":"Structurally important","evidences":[{"source":"PubMed","id":"14661964","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for channel affinity","evidences":[{"source":"PubMed","id":"8798612","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Site: {"description":"Not important for channel affinity and toxin structure","evidences":[{"source":"PubMed","id":"8639500","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for channel affinity (interacts with rat Nav1.5 channel residue Asp-1612)","evidences":[{"source":"PubMed","id":"8639500","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9417050","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Site: {"description":"Structurally important","evidences":[{"source":"PubMed","id":"8621610","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Site: {"description":"Does not affect binding, but may affect the stabilization of the cardiac channel open conformation","evidences":[{"source":"PubMed","id":"8798612","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | Site: {"description":"Binds to sodium channel","evidences":[{"source":"PubMed","id":"8288644","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for most of the cardiac specificity","evidences":[{"source":"PubMed","id":"8276803","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
