1ANW

THE EFFECT OF METAL BINDING ON THE STRUCTURE OF ANNEXIN V AND IMPLICATIONS FOR MEMBRANE BINDING

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001786	molecular_function	phosphatidylserine binding
A	0004859	molecular_function	phospholipase inhibitor activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005544	molecular_function	calcium-dependent phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0007165	biological_process	signal transduction
A	0009897	cellular_component	external side of plasma membrane
A	0012506	cellular_component	vesicle membrane
A	0016020	cellular_component	membrane
A	0031012	cellular_component	extracellular matrix
A	0042383	cellular_component	sarcolemma
A	0043066	biological_process	negative regulation of apoptotic process
A	0050819	biological_process	negative regulation of coagulation
A	0070062	cellular_component	extracellular exosome
A	0072563	cellular_component	endothelial microparticle
B	0001786	molecular_function	phosphatidylserine binding
B	0004859	molecular_function	phospholipase inhibitor activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005543	molecular_function	phospholipid binding
B	0005544	molecular_function	calcium-dependent phospholipid binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005925	cellular_component	focal adhesion
B	0007165	biological_process	signal transduction
B	0009897	cellular_component	external side of plasma membrane
B	0012506	cellular_component	vesicle membrane
B	0016020	cellular_component	membrane
B	0031012	cellular_component	extracellular matrix
B	0042383	cellular_component	sarcolemma
B	0043066	biological_process	negative regulation of apoptotic process
B	0050819	biological_process	negative regulation of coagulation
B	0070062	cellular_component	extracellular exosome
B	0072563	cellular_component	endothelial microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 351

Chain	Residue
A	MET28
A	GLY30
A	GLY32
A	GLU72
A	HOH823

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 352

Chain	Residue
A	HOH902
A	HOH981
A	MET259
A	GLY261
A	GLY263
A	ASP303

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 353

Chain	Residue
B	MET28
B	GLY30
B	GLY32
B	GLU72
B	HOH757
B	HOH861

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 354

Chain	Residue
B	MET259
B	GLY261
B	GLY263
B	ASP303
B	HOH891

---

Functional Information from PROSITE/UniProt

site_id	PS00223
Number of Residues	53
Details	ANNEXIN_1 Annexin repeat signature. GTdeesiltlLtsRsnaQrqEisaaFktlfgrdLlddLkseltGkfeklIvaL

Chain	Residue	Details
A	GLY32-LEU84
A	GLY104-LEU156
A	GLY188-VAL240
A	GLY263-LEU315

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	142
Details	Repeat: {"description":"Annexin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	142
Details	Repeat: {"description":"Annexin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	144
Details	Repeat: {"description":"Annexin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	142
Details	Repeat: {"description":"Annexin 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Motif: {"description":"[IL]-x-C-x-x-[DE] motif","evidences":[{"source":"PubMed","id":"25417112","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P48036","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"16916647","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P48036","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---