Functional Information from GO Data
| Chain | GOid | namespace | contents |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005615 | cellular_component | extracellular space |
| E | 0006508 | biological_process | proteolysis |
| E | 0007586 | biological_process | digestion |
| E | 0008236 | molecular_function | serine-type peptidase activity |
| E | 0046872 | molecular_function | metal ion binding |
| I | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| I | 0005615 | cellular_component | extracellular space |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA E 300 |
| Chain | Residue |
| E | GLU70 |
| E | ASN72 |
| E | VAL75 |
| E | GLU77 |
| E | GLU80 |
| E | HOH355 |
| site_id | CA |
| Number of Residues | 1 |
| Details | CALCIUM+2 ION BINDING SITE IN TRYPSIN. BOUND THROUGH SIDE CHAINS OF GLUE 70, GLU E 77, GLU E 80, PEPTIDE CARBONYLS OF ASN E 72 AND VAL E 75 AND HOH 75. |
| site_id | P1 |
| Number of Residues | 1 |
| Details | BINDING LOOP OF LDTI. LYS I 8 IS THE PRIMARY SPECIFICITY. |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC |
| Chain | Residue | Details |
| E | VAL53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV |
| Chain | Residue | Details |
| E | ASP189-VAL200 | |
| site_id | PS00282 |
| Number of Residues | 24 |
| Details | KAZAL_1 Kazal serine protease inhibitors family signature. CpkilKpvCgSdgrtYansCiarC |
| Chain | Residue | Details |
| I | CYS6-CYS29 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | SITE: Reactive bond (tryptase) |
| Chain | Residue | Details |
| I | LYS8 | |
| E | ASP102 | |
| E | SER195 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| E | VAL75 | |
| E | GLU80 | |
| E | GLU70 | |
| E | ASN72 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Required for specificity => ECO:0000250 |
| Chain | Residue | Details |
| E | ASP189 | |
