Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001869 | biological_process | negative regulation of complement activation, lectin pathway |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0010765 | biological_process | positive regulation of sodium ion transport |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0045959 | biological_process | negative regulation of complement activation, classical pathway |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0141141 | biological_process | symbiont-mediated evasion of recognition by host pattern recognition receptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 500 |
| Chain | Residue |
| A | HOH1061 |
| A | HIS176 |
| A | HIS180 |
| A | HIS186 |
| A | TYR216 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 501 |
| Chain | Residue |
| A | ARG253 |
| A | GLY255 |
| A | THR257 |
| A | ASP285 |
| A | GLY287 |
| A | ASP290 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 502 |
| Chain | Residue |
| A | GLY288 |
| A | ASP290 |
| A | THR327 |
| A | GLU329 |
| A | HOH1028 |
| A | HOH1252 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 503 |
| Chain | Residue |
| A | GLY334 |
| A | GLY336 |
| A | ASP338 |
| A | GLY351 |
| A | ALA353 |
| A | ASP356 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CA A 504 |
| Chain | Residue |
| A | GLY352 |
| A | ALA353 |
| A | GLY354 |
| A | ASP356 |
| A | GLY369 |
| A | GLY370 |
| A | ALA371 |
| A | ASP374 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 505 |
| Chain | Residue |
| A | GLY370 |
| A | GLY372 |
| A | ASP374 |
| A | GLN399 |
| A | ASP400 |
| A | HOH1160 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 506 |
| Chain | Residue |
| A | ASN343 |
| A | VAL345 |
| A | ASN347 |
| A | GLY360 |
| A | LEU362 |
| A | ASP365 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 507 |
| Chain | Residue |
| A | GLY361 |
| A | GLY363 |
| A | ASP365 |
| A | GLU383 |
| A | ASP390 |
| A | HOH1313 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 508 |
| Chain | Residue |
| A | ASP446 |
| A | SER448 |
| A | ASP450 |
| A | HIS452 |
| A | ASP454 |
| site_id | CAT |
| Number of Residues | 5 |
| Details | THE ZINC ION AT THE BOTTOM OF CATALYTIC CLEFT HAS FIVE LIGANDS |
| Chain | Residue |
| A | HIS176 |
| A | HIS180 |
| A | HIS186 |
| A | TYR216 |
| A | HOH1061 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLTHEIGHTL |
| Chain | Residue | Details |
| A | THR173-LEU182 | |
| site_id | PS00330 |
| Number of Residues | 19 |
| Details | HEMOLYSIN_CALCIUM Hemolysin-type calcium-binding region signature. DiLygglGaDqLwGGagaD |
| Chain | Residue | Details |
| A | ASP356-ASP374 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 13 |
| Details | Repeat: {"description":"Hemolysin-type calcium-binding 1","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Repeat: {"description":"Hemolysin-type calcium-binding 2","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 17 |
| Details | Repeat: {"description":"Hemolysin-type calcium-binding 3","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 41 |
| Details | Binding site: {} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | GLU177 | |
| A | GLU194 | |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | GLU177 | |
