1AK5

INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH) FROM TRITRICHOMONAS FOETUS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006177	biological_process	GMP biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 600

Chain	Residue
A	GLY381
A	ARG382
A	TYR405
A	HOH1011

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Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. IKIGIGgGSICiT

Chain	Residue	Details
A	ILE309-THR321

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:12235158, ECO:0000269|PubMed:12549902

Chain	Residue	Details
A	CYS319

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_03156

Chain	Residue	Details
A	ARG418

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: in other chain => ECO:0000269|PubMed:12549902

Chain	Residue	Details
A	GLY20
A	SER22
A	GLY314
A	GLY316
A	CYS319
A	ASN460

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site_id	SWS_FT_FI4
Number of Residues	7
Details	BINDING:

Chain	Residue	Details
A	ASP261
A	GLY312
A	SER317
A	ASP358
A	GLY381
A	TYR405
A	GLU431

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site_id	SWS_FT_FI5
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:12549902

Chain	Residue	Details
A	ASP264
A	PHE266
A	GLU485
A	GLY486
A	GLY487

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