1AHH
7 ALPHA-HYDROXYSTEROID DEHYDROGENASE COMPLEXED WITH NAD+
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005829 | cellular_component | cytosol |
A | 0008709 | molecular_function | cholate 7-alpha-dehydrogenase activity |
A | 0016042 | biological_process | lipid catabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0030573 | biological_process | bile acid catabolic process |
A | 0032991 | cellular_component | protein-containing complex |
A | 0042802 | molecular_function | identical protein binding |
A | 0051287 | molecular_function | NAD binding |
A | 0106281 | molecular_function | chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity |
B | 0005829 | cellular_component | cytosol |
B | 0008709 | molecular_function | cholate 7-alpha-dehydrogenase activity |
B | 0016042 | biological_process | lipid catabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0030573 | biological_process | bile acid catabolic process |
B | 0032991 | cellular_component | protein-containing complex |
B | 0042802 | molecular_function | identical protein binding |
B | 0051287 | molecular_function | NAD binding |
B | 0106281 | molecular_function | chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE NAD A 256 |
Chain | Residue |
A | GLY18 |
A | GLY97 |
A | GLY98 |
A | ILE144 |
A | THR145 |
A | TYR159 |
A | LYS163 |
A | PRO189 |
A | GLY190 |
A | ILE192 |
A | THR194 |
A | ALA21 |
A | HOH259 |
A | HOH294 |
A | ILE23 |
A | ASP42 |
A | ILE43 |
A | CYS67 |
A | ASP68 |
A | ILE69 |
A | ASN95 |
site_id | AC2 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE NAD B 256 |
Chain | Residue |
B | GLY18 |
B | ALA21 |
B | ILE23 |
B | ASP42 |
B | ILE43 |
B | CYS67 |
B | ASP68 |
B | ILE69 |
B | ASN95 |
B | GLY97 |
B | ILE144 |
B | THR145 |
B | LYS163 |
B | PRO189 |
B | GLY190 |
B | ILE192 |
B | HOH259 |
Functional Information from PROSITE/UniProt
site_id | PS00061 |
Number of Residues | 29 |
Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SmaaenkninMtsYASSKAAAsHLVrNMA |
Chain | Residue | Details |
A | SER146-ALA174 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:8672472, ECO:0000305|PubMed:9722677 |
Chain | Residue | Details |
A | TYR159 | |
B | TYR159 |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC |
Chain | Residue | Details |
A | ILE23 | |
B | TYR159 | |
A | GLY99 | |
A | SER146 | |
A | ASN151 | |
A | TYR159 | |
B | ILE23 | |
B | GLY99 | |
B | SER146 | |
B | ASN151 |
site_id | SWS_FT_FI3 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8672472, ECO:0007744|PDB:1AHH, ECO:0007744|PDB:1AHI, ECO:0007744|PDB:1FMC |
Chain | Residue | Details |
A | ASP42 | |
B | ILE192 | |
A | ASP68 | |
A | ASN95 | |
A | LYS163 | |
A | ILE192 | |
B | ASP42 | |
B | ASP68 | |
B | ASN95 | |
B | LYS163 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Transition state stabilizer => ECO:0000305|PubMed:8672472, ECO:0000305|PubMed:9722677 |
Chain | Residue | Details |
A | SER146 | |
B | SER146 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | SITE: Lowers pKa of active site Tyr => ECO:0000305|PubMed:8672472, ECO:0000305|PubMed:9722677 |
Chain | Residue | Details |
A | LYS163 | |
B | LYS163 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1ybv |
Chain | Residue | Details |
A | ASN118 | |
A | SER146 | |
A | TYR159 | |
A | LYS163 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1ybv |
Chain | Residue | Details |
B | ASN118 | |
B | SER146 | |
B | TYR159 | |
B | LYS163 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ybv |
Chain | Residue | Details |
A | MET156 | |
A | LYS163 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ybv |
Chain | Residue | Details |
B | MET156 | |
B | LYS163 |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ybv |
Chain | Residue | Details |
A | TYR159 | |
A | LYS163 |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ybv |
Chain | Residue | Details |
B | TYR159 | |
B | LYS163 |