1AHE

ASPARTATE AMINOTRANSFERASE HEXAMUTANT

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0042802molecular_functionidentical protein binding
A0004069molecular_functionL-aspartate:2-oxoglutarate aminotransferase activity
A0004838molecular_functionL-tyrosine:2-oxoglutarate aminotransferase activity
A0030170molecular_functionpyridoxal phosphate binding
A0009094biological_processL-phenylalanine biosynthetic process
A0033585biological_processL-phenylalanine biosynthetic process from chorismate via phenylpyruvate
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0042802molecular_functionidentical protein binding
B0004069molecular_functionL-aspartate:2-oxoglutarate aminotransferase activity
B0004838molecular_functionL-tyrosine:2-oxoglutarate aminotransferase activity
B0030170molecular_functionpyridoxal phosphate binding
B0009094biological_processL-phenylalanine biosynthetic process
B0033585biological_processL-phenylalanine biosynthetic process from chorismate via phenylpyruvate
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
ACT24
ChainResidue
AASP15
AILE17
ALEU18
AILE37
AGLY38
ALEU39
BTYR70
AGLY107
AGLY108
ASER109
ATRP140
AASN194
AASP222
AALA224
ATYR225
ASER255
ALYS258
AARG266
BARG292
BSER296
BSER297
APHE360
AARG386
ASO4411

BCT24
ChainResidue
BASP15
BILE17
BLEU18
BILE37
BGLY38
BLEU39
ATYR70
BGLY107
BGLY108
BSER109
BTRP140
BASN194
BASP222
BALA224
BTYR225
BSER255
BLYS258
BARG266
AARG292
ASER296
ASER297
BPHE360
BARG386
BSO4411

AC18BINDING SITE FOR RESIDUE SO4 A 411
ChainResidue
AILE17
AILE37
AGLY38
ATRP140
AASN194
ATYR225
APHE360
AARG386

AC27BINDING SITE FOR RESIDUE SO4 B 411
ChainResidue
BILE17
BILE37
BGLY38
BTRP140
BASN194
BTYR225
BARG386

AC312BINDING SITE FOR RESIDUE PLP A 412
ChainResidue
AGLY107
AGLY108
ASER109
ATRP140
AASN194
AASP222
ATYR225
ASER255
ASER257
ALYS258
AARG266
BTYR70

AC413BINDING SITE FOR RESIDUE PLP B 412
ChainResidue
ATYR70
BGLY107
BGLY108
BSER109
BTRP140
BASN194
BASP222
BALA224
BTYR225
BSER255
BSER257
BLYS258
BARG266

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
PLP_1ahe_B_41222PYRIDOXAL-5'-PHOSPHATE binding site
ChainResidueligand
ATYR70PLP: PYRIDOXAL-5'-PHOSPHATE
ASER296PLP: PYRIDOXAL-5'-PHOSPHATE
BPRO106-GLY110PLP: PYRIDOXAL-5'-PHOSPHATE
BLEU112PLP: PYRIDOXAL-5'-PHOSPHATE
BTRP140PLP: PYRIDOXAL-5'-PHOSPHATE
BHIS143PLP: PYRIDOXAL-5'-PHOSPHATE
BHIS189PLP: PYRIDOXAL-5'-PHOSPHATE
BASN194PLP: PYRIDOXAL-5'-PHOSPHATE
BASP222PLP: PYRIDOXAL-5'-PHOSPHATE
BALA224-TYR225PLP: PYRIDOXAL-5'-PHOSPHATE
BSER255-LYS258PLP: PYRIDOXAL-5'-PHOSPHATE
BTYR263PLP: PYRIDOXAL-5'-PHOSPHATE
BARG266-VAL267PLP: PYRIDOXAL-5'-PHOSPHATE

PLP_1ahe_A_41221PYRIDOXAL-5'-PHOSPHATE binding site
ChainResidueligand
APRO106-GLY110PLP: PYRIDOXAL-5'-PHOSPHATE
ALEU112PLP: PYRIDOXAL-5'-PHOSPHATE
ATRP140PLP: PYRIDOXAL-5'-PHOSPHATE
AHIS143PLP: PYRIDOXAL-5'-PHOSPHATE
AHIS189PLP: PYRIDOXAL-5'-PHOSPHATE
AASN194PLP: PYRIDOXAL-5'-PHOSPHATE
AASP222PLP: PYRIDOXAL-5'-PHOSPHATE
AALA224-TYR225PLP: PYRIDOXAL-5'-PHOSPHATE
ASER255-LYS258PLP: PYRIDOXAL-5'-PHOSPHATE
AARG266-VAL267PLP: PYRIDOXAL-5'-PHOSPHATE
BTYR70PLP: PYRIDOXAL-5'-PHOSPHATE
BTYR295PLP: PYRIDOXAL-5'-PHOSPHATE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS0010528Aminotransferases class-I pyridoxal-phosphate attachment site. [GS]-[LIVMFYTAC]-[GSTA]-K-x(2)-[GSALVN]-[LIVMFA]-x-[GNAR]-{V}-R-[LIVMA]
ChainResidueDetails
ASER255-GLY268
BSER255-GLY268

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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI13Aspartate.
ChainResidueDetails
ATRP130
AASN183
AARG374

SWS_FT_FI21Aspartate; via amide nitrogen.
ChainResidueDetails
AGLY34

SWS_FT_FI33Aspartate.
ChainResidueDetails
BTRP130
BASN183
BARG374

SWS_FT_FI41Aspartate; via amide nitrogen.
ChainResidueDetails
BGLY34

CSA12Annotated By Reference To The Literature 1ay4
ChainResidueDetails
ATRP140
AASP222

CSA22Annotated By Reference To The Literature 1ay4
ChainResidueDetails
BTRP140
BASP222

CSA33Annotated By Reference To The Literature 1ay4
ChainResidueDetails
ATRP140
AASP222
ALYS258

CSA43Annotated By Reference To The Literature 1ay4
ChainResidueDetails
BTRP140
BASP222
BLYS258

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Catalytic Information from CSA

site_idNumber of ResiduesDetails
CSA12Annotated By Reference To The Literature 1ay4
ChainResidueDetails
ATRP140
AASP222

CSA22Annotated By Reference To The Literature 1ay4
ChainResidueDetails
BTRP140
BASP222

CSA33Annotated By Reference To The Literature 1ay4
ChainResidueDetails
ATRP140
AASP222
ALYS258

CSA43Annotated By Reference To The Literature 1ay4
ChainResidueDetails
BTRP140
BASP222
BLYS258