1AH5
REDUCED FORM SELENOMETHIONINE-LABELLED HYDROXYMETHYLBILANE SYNTHASE DETERMINED BY MAD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004418 | molecular_function | hydroxymethylbilane synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| A | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| A | 0006783 | biological_process | heme biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018160 | biological_process | peptidyl-pyrromethane cofactor linkage |
| A | 0033014 | biological_process | tetrapyrrole biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE DPM A 314 |
| Chain | Residue |
| A | LEU15 |
| A | LEU148 |
| A | ARG155 |
| A | LEU169 |
| A | ALA170 |
| A | GLN198 |
| A | GLY199 |
| A | CYS242 |
| A | GLN243 |
| A | HOH351 |
| A | HOH373 |
| A | SER81 |
| A | HOH422 |
| A | HOH445 |
| A | HOH454 |
| A | LYS83 |
| A | ASP84 |
| A | THR127 |
| A | SER128 |
| A | SER129 |
| A | ARG131 |
| A | ARG132 |
Functional Information from PROSITE/UniProt
| site_id | PS00533 |
| Number of Residues | 17 |
| Details | PORPHOBILINOGEN_DEAM Porphobilinogen deaminase cofactor-binding site. ERaMntrLeGGCqVPIG |
| Chain | Residue | Details |
| A | GLU231-GLY247 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"S-(dipyrrolylmethanemethyl)cysteine"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 2ypn |
| Chain | Residue | Details |
| A | CYS242 | |
| A | ARG155 | |
| A | ASP84 | |
| A | ARG131 | |
| A | ARG149 | |
| A | ARG132 |
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 260 |
| Chain | Residue | Details |
| A | LEU95 | activator, electrostatic stabiliser, hydrogen bond donor |
| A | VAL96 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | LEU143 | activator, electrostatic stabiliser, hydrogen bond donor |
| A | ILE144 | activator, electrostatic stabiliser, hydrogen bond donor |
| A | ASN161 | activator, electrostatic stabiliser |
| A | ILE167 | activator, electrostatic stabiliser |
| A | TRP258 | covalently attached |
