1AGI
CRYSTAL STRUCTURE OF BOVINE ANGIOGENIN AT 1.5 ANGSTROMS RESOLUTION
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0001541 | biological_process | ovarian follicle development |
| A | 0001666 | biological_process | response to hypoxia |
| A | 0001938 | biological_process | positive regulation of endothelial cell proliferation |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003779 | molecular_function | actin binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005507 | molecular_function | copper ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005604 | cellular_component | basement membrane |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005730 | cellular_component | nucleolus |
| A | 0008201 | molecular_function | heparin binding |
| A | 0009303 | biological_process | rRNA transcription |
| A | 0010494 | cellular_component | cytoplasmic stress granule |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017148 | biological_process | negative regulation of translation |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0023052 | biological_process | signaling |
| A | 0030041 | biological_process | actin filament polymerization |
| A | 0030154 | biological_process | cell differentiation |
| A | 0030426 | cellular_component | growth cone |
| A | 0032311 | cellular_component | angiogenin-PRI complex |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0045087 | biological_process | innate immune response |
| A | 0048662 | biological_process | negative regulation of smooth muscle cell proliferation |
| A | 0050714 | biological_process | positive regulation of protein secretion |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
Functional Information from PDB Data
| site_id | PRS |
| Number of Residues | 17 |
| Details |
| Chain | Residue |
| A | GLU59 |
| A | ASP60 |
| A | ARG61 |
| A | ASN62 |
| A | GLY63 |
| A | GLN64 |
| A | PRO65 |
| A | TYR66 |
| A | ARG67 |
| A | GLY68 |
| A | ASP69 |
| A | LEU70 |
| A | ARG71 |
| A | GLU109 |
| A | ASN110 |
| A | GLY111 |
| A | LEU112 |
| site_id | RAS |
| Number of Residues | 12 |
| Details |
| Chain | Residue |
| A | GLN13 |
| A | GLU118 |
| A | SER119 |
| A | PHE120 |
| A | HIS14 |
| A | LYS41 |
| A | ARG43 |
| A | ASN44 |
| A | THR45 |
| A | HIS115 |
| A | PHE116 |
| A | ASP117 |
Functional Information from PROSITE/UniProt
| site_id | PS00127 |
| Number of Residues | 7 |
| Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKdrNTF |
| Chain | Residue | Details |
| A | CYS40-PHE46 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Motif: {"description":"Nucleolar localization signal","evidences":[{"source":"UniProtKB","id":"P03950","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P03950","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P03950","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P03950","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rbn |
| Chain | Residue | Details |
| A | HIS14 | |
| A | PHE116 | |
| A | HIS115 | |
| A | LYS41 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1rbn |
| Chain | Residue | Details |
| A | HIS14 | |
| A | HIS115 | |
| A | LYS41 |
