Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1AEI

CRYSTAL STRUCTURE OF THE ANNEXIN XII HEXAMER

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001786	molecular_function	phosphatidylserine binding
A	0005509	molecular_function	calcium ion binding
A	0005544	molecular_function	calcium-dependent phospholipid binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0012506	cellular_component	vesicle membrane
B	0001786	molecular_function	phosphatidylserine binding
B	0005509	molecular_function	calcium ion binding
B	0005544	molecular_function	calcium-dependent phospholipid binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0012506	cellular_component	vesicle membrane
C	0001786	molecular_function	phosphatidylserine binding
C	0005509	molecular_function	calcium ion binding
C	0005544	molecular_function	calcium-dependent phospholipid binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0012506	cellular_component	vesicle membrane
D	0001786	molecular_function	phosphatidylserine binding
D	0005509	molecular_function	calcium ion binding
D	0005544	molecular_function	calcium-dependent phospholipid binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0012506	cellular_component	vesicle membrane
E	0001786	molecular_function	phosphatidylserine binding
E	0005509	molecular_function	calcium ion binding
E	0005544	molecular_function	calcium-dependent phospholipid binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0012506	cellular_component	vesicle membrane
F	0001786	molecular_function	phosphatidylserine binding
F	0005509	molecular_function	calcium ion binding
F	0005544	molecular_function	calcium-dependent phospholipid binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0012506	cellular_component	vesicle membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 1

Chain	Residue
A	GLU105
E	LYS68
E	LEU71
E	GLU76

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA D 317

Chain	Residue
B	GLU105
D	LYS68
D	LEU71
D	GLU76

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA F 317

Chain	Residue
F	LYS68
F	LEU71
F	GLU76
C	GLU105

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 317

Chain	Residue
B	LYS68
B	LEU71
B	GLU76
D	GLU105

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 317

Chain	Residue
A	LYS68
A	LEU71
A	GLU76
E	GLU105

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 317

Chain	Residue
C	LYS68
C	LEU71
C	GLU76
F	GLU105

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 318

Chain	Residue
A	MET26
A	GLY28
A	GLY30
A	GLU70

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 318

Chain	Residue
B	MET26
B	GLY28
B	GLY30
B	GLU70

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 318

Chain	Residue
C	MET26
C	GLY28
C	GLY30
C	GLU70

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA D 318

Chain	Residue
D	MET26
D	GLY28
D	GLY30
D	GLU70

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 317

Chain	Residue
E	MET26
E	GLY28
E	GLY30
E	GLU70

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA F 318

Chain	Residue
F	MET26
F	GLY28
F	GLY30
F	GLU70

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 319

Chain	Residue
A	GLY181
A	GLN184
A	ILE185
A	GLY186
A	GLU226

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 319

Chain	Residue
B	GLY181
B	GLN184
B	ILE185
B	GLY186
B	GLU226

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 319

Chain	Residue
C	GLY181
C	GLN184
C	ILE185
C	GLY186
C	GLU226

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 319

Chain	Residue
D	GLY181
D	GLN184
D	ILE185
D	GLY186
D	GLU226

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA E 318

Chain	Residue
E	GLY181
E	GLN184
E	ILE185
E	GLY186
E	GLU226

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 319

Chain	Residue
F	GLY181
F	GLN184
F	ILE185
F	GLY186
F	GLU226

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 320

Chain	Residue
A	MET257
A	LYS258
A	GLY259
A	GLY261
A	ASP301

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 320

Chain	Residue
B	MET257
B	LYS258
B	GLY259
B	GLY261
B	ASP301

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 320

Chain	Residue
C	MET257
C	GLY259
C	GLY261
C	ASP301

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 320

Chain	Residue
D	MET257
D	LYS258
D	GLY259
D	GLY261
D	ASP301

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA E 319

Chain	Residue
E	GLY259
E	GLY261
E	ASP301
E	MET257
E	LYS258

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 320

Chain	Residue
F	MET257
F	LYS258
F	GLY259
F	GLY261
F	ASP301

Functional Information from PROSITE/UniProt

site_id	PS00223
Number of Residues	53
Details	ANNEXIN_1 Annexin repeat signature. GTdeksithiLatRsnaQrqQiktdYttlfgkhLedeLkselsGnyeaaAlaL

Chain	Residue	Details
A	GLY30-LEU82
A	GLY186-ILE238
A	GLY261-ILE313

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	426
Details	Repeat: {"description":"Annexin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	426
Details	Repeat: {"description":"Annexin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	432
Details	Repeat: {"description":"Annexin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	426
Details	Repeat: {"description":"Annexin 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)