1AEC

CRYSTAL STRUCTURE OF ACTINIDIN-E-64 COMPLEX+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE E64 A 219

Chain	Residue
A	GLN19
A	GLY68
A	TYR69
A	ASN88
A	ASP161
A	HIS162
A	HOH272
A	HOH305
A	HOH481
A	HOH485
A	GLY23
A	GLY24
A	CYS25
A	TRP26
A	ASN61
A	ARG63
A	ASN66
A	GLY67

---

Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGeCGGCWAfSA

Chain	Residue	Details
A	GLN19-ALA30

---

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. IDHAVTIVGYG

Chain	Residue	Details
A	ILE160-GLY170

---

site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWIvKNSWdttWGeeGYMrI

Chain	Residue	Details
A	TYR177-ILE196

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10088, ECO:0000305|PubMed:1606141, ECO:0007744|PDB:1AEC

Chain	Residue	Details
A	CYS25

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10089

Chain	Residue	Details
A	HIS162

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090

Chain	Residue	Details
A	ASN182

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: covalent => ECO:0000269|PubMed:1606141, ECO:0007744|PDB:1AEC

Chain	Residue	Details
A	CYS25

---