1AD3
CLASS 3 ALDEHYDE DEHYDROGENASE COMPLEX WITH NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001666 | biological_process | response to hypoxia |
| A | 0004028 | molecular_function | 3-chloroallyl aldehyde dehydrogenase activity |
| A | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| A | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006081 | biological_process | aldehyde metabolic process |
| A | 0007584 | biological_process | response to nutrient |
| A | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0051384 | biological_process | response to glucocorticoid |
| A | 0051591 | biological_process | response to cAMP |
| B | 0001666 | biological_process | response to hypoxia |
| B | 0004028 | molecular_function | 3-chloroallyl aldehyde dehydrogenase activity |
| B | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| B | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006081 | biological_process | aldehyde metabolic process |
| B | 0007584 | biological_process | response to nutrient |
| B | 0008106 | molecular_function | alcohol dehydrogenase (NADP+) activity |
| B | 0008284 | biological_process | positive regulation of cell population proliferation |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0051384 | biological_process | response to glucocorticoid |
| B | 0051591 | biological_process | response to cAMP |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NAD A 600 |
| Chain | Residue |
| A | GLY187 |
| A | VAL191 |
| A | ILE194 |
| A | HIS289 |
| A | ARG292 |
| A | GLU333 |
| A | PHE335 |
| A | HOH606 |
| A | HOH617 |
| A | ALA112 |
| A | TRP113 |
| A | ASN114 |
| A | GLU140 |
| A | VAL141 |
| A | GLY168 |
| A | VAL169 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE NAD B 600 |
| Chain | Residue |
| B | ALA112 |
| B | TRP113 |
| B | ASN114 |
| B | GLU140 |
| B | VAL141 |
| B | GLY168 |
| B | VAL169 |
| B | VAL191 |
| B | HIS289 |
| B | ARG292 |
| B | GLU333 |
| B | PHE335 |
| site_id | CTA |
| Number of Residues | 1 |
| Details | CATALYTIC CYSTEINE |
| Chain | Residue |
| A | CYS216 |
| site_id | CTB |
| Number of Residues | 1 |
| Details | CATALYTIC CYSTEINE |
| Chain | Residue |
| B | CYS216 |
Functional Information from PROSITE/UniProt
| site_id | PS00070 |
| Number of Residues | 12 |
| Details | ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FmNSGQTCVAPD |
| Chain | Residue | Details |
| A | PHE236-ASP247 |
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP |
| Chain | Residue | Details |
| A | LEU208-PRO215 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P30838","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| A | CYS243 | |
| A | GLU209 | |
| A | ASN114 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| B | CYS243 | |
| B | GLU209 | |
| B | ASN114 |
