1ABR
CRYSTAL STRUCTURE OF ABRIN-A
Functional Information from GO Data
Functional Information from PDB Data
| site_id | ACT |
| Number of Residues | 10 |
| Details | ACTIVE SITE CLEFT OF ABRIN-A A-CHAIN CONTAINS 5 INVARIANT AND 5 CONSERVED RESIDUES. THE FIRST 5 RESIDUES IN THE LIST ARE INVARIANT RESIDUES. |
| Chain | Residue |
| A | TYR74 |
| A | ASN196 |
| A | TYR113 |
| A | GLU164 |
| A | ARG167 |
| A | TRP198 |
| A | ASN72 |
| A | ARG124 |
| A | GLN160 |
| A | GLU195 |
| site_id | GL1 |
| Number of Residues | 2 |
| Details | THE FIRST GLYCOSYLATION SITE OF ABRIN-A B-CHAIN BINDS N-ACETYLGLYCOSAMINE, NDG1, OF FIRST SUGAR CHAIN PRESENTED WITH INSERTION CODE C. |
| Chain | Residue |
| B | ASN100 |
| B | TYR130 |
| site_id | GL2 |
| Number of Residues | 1 |
| Details | THE SECOND GLYCOSYLATION SITE OF ABRIN-A B-CHAIN BINDS N-ACETYLGLYCOSAMINES, NDG1 AND NDG2, OF THE SECOND SUGAR CHAIN PRESENTED WITH INSERTION CODE D. |
| Chain | Residue |
| B | ASN140 |
| site_id | SU1 |
| Number of Residues | 2 |
| Details | THE FIRST SUGAR BINDING SITE OF ABRIN-A B-CHAIN BINDS MANNOSE, MAN4, OF THE SUGAR CHAIN WHICH SYMMETRICALLY RELATED TO THE FIRST SUGAR CHAIN IDENTIFIED WITH INSERTION CODE C. |
| Chain | Residue |
| B | ASN31 |
| B | ASN51 |
| site_id | SU2 |
| Number of Residues | 1 |
| Details | THE POTENTIAL SECOND SUGAR BINDING SITE OF ABRIN-A B-CHAIN. THIS IS NOT CONFIRMED BY CURRENT STRUCTURE. |
| Chain | Residue |
| B | ASN260 |
Functional Information from PROSITE/UniProt
| site_id | PS00275 |
| Number of Residues | 17 |
| Details | SHIGA_RICIN Shiga/ricin ribosomal inactivating toxins active site signature. IqMVaEAARFRyISnrV |
| Chain | Residue | Details |
| A | ILE159-VAL175 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"1988","firstPage":"1095","lastPage":"1097","volume":"52","journal":"Agric. Biol. Chem.","title":"The complete amino acid sequence of the A-chain of abrin-a, a toxic protein from the seeds of Abrus precatorius.","authors":["Funatsu G.","Taguchi Y.","Kamenosono M.","Yanaka M."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 127 |
| Details | Domain: {"description":"Ricin B-type lectin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00174","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"1-alpha"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"1-beta"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"1-gamma"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 124 |
| Details | Domain: {"description":"Ricin B-type lectin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00174","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"2-alpha"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"2-beta"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"2-gamma"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 7608980, 1433290 |
| Chain | Residue | Details |
| A | GLU164 | |
| A | ARG167 |
