1AB4

59KDA FRAGMENT OF GYRASE A FROM E. COLI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01897","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3031051","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	a catalytic site defined by CSA, PubMed 12051843

Chain	Residue	Details
A	TYR122
A	ARG32
A	HIS78

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site_id	MCSA1
Number of Residues	3
Details	M-CSA 745

Chain	Residue	Details
A	ARG32	electrostatic stabiliser
A	HIS78	proton acceptor
A	TYR122	metal ligand, nucleofuge, nucleophile, proton acceptor, proton donor

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