1AAT

OXOGLUTARATE-INDUCED CONFORMATIONAL CHANGES IN CYTOSOLIC ASPARTATE AMINOTRANSFERASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004069	molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity
A	0004609	molecular_function	phosphatidylserine decarboxylase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006103	biological_process	2-oxoglutarate metabolic process
A	0006114	biological_process	glycerol biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0006531	biological_process	aspartate metabolic process
A	0006532	biological_process	aspartate biosynthetic process
A	0006533	biological_process	L-aspartate catabolic process
A	0006536	biological_process	glutamate metabolic process
A	0008483	molecular_function	transaminase activity
A	0008652	biological_process	amino acid biosynthetic process
A	0009058	biological_process	biosynthetic process
A	0016740	molecular_function	transferase activity
A	0030170	molecular_function	pyridoxal phosphate binding
A	0032869	biological_process	cellular response to insulin stimulus
A	0043490	biological_process	malate-aspartate shuttle
A	0047801	molecular_function	L-cysteine transaminase activity
A	0051384	biological_process	response to glucocorticoid
A	0120554	molecular_function	2-aminobutanoate transaminase activity
A	0170033	biological_process	L-amino acid metabolic process
B	0003824	molecular_function	catalytic activity
B	0004069	molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity
B	0004609	molecular_function	phosphatidylserine decarboxylase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006103	biological_process	2-oxoglutarate metabolic process
B	0006114	biological_process	glycerol biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0006531	biological_process	aspartate metabolic process
B	0006532	biological_process	aspartate biosynthetic process
B	0006533	biological_process	L-aspartate catabolic process
B	0006536	biological_process	glutamate metabolic process
B	0008483	molecular_function	transaminase activity
B	0008652	biological_process	amino acid biosynthetic process
B	0009058	biological_process	biosynthetic process
B	0016740	molecular_function	transferase activity
B	0030170	molecular_function	pyridoxal phosphate binding
B	0032869	biological_process	cellular response to insulin stimulus
B	0043490	biological_process	malate-aspartate shuttle
B	0047801	molecular_function	L-cysteine transaminase activity
B	0051384	biological_process	response to glucocorticoid
B	0120554	molecular_function	2-aminobutanoate transaminase activity
B	0170033	biological_process	L-amino acid metabolic process

Functional Information from PDB Data

site_id	OG
Number of Residues	5
Details	2-OXOGLUTARATE BINDING SITE

Chain	Residue
A	TRP140
A	ASN194
A	ARG386
B	TYR70
B	ARG292

---

site_id	PLP
Number of Residues	12
Details	PYRIDOXAL PHOSPHATE BINDING SITE

Chain	Residue
A	GLY107
A	ARG266
B	TYR70
B	SER296
A	GLY108
A	THR109
A	TRP140
A	ASP222
A	TYR225
A	SER255
A	SER257
A	LYS258

---

Functional Information from PROSITE/UniProt

site_id	PS00105
Number of Residues	14
Details	AA_TRANSFER_CLASS_1 Aminotransferases class-I pyridoxal-phosphate attachment site. SFSKnfGLyNERVG

Chain	Residue	Details
A	SER255-GLY268

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"499525","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine"}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
A	TRP140
A	ASP222

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
B	TRP140
B	ASP222

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
A	TRP140
A	ASP222
A	LYS258

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
B	TRP140
B	ASP222
B	LYS258

---