Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1A9W

HUMAN EMBRYONIC GOWER II CARBONMONOXY HEMOGLOBIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005829	cellular_component	cytosol
A	0005833	cellular_component	hemoglobin complex
A	0015670	biological_process	carbon dioxide transport
A	0015671	biological_process	oxygen transport
A	0016020	cellular_component	membrane
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0030185	biological_process	nitric oxide transport
A	0031720	molecular_function	haptoglobin binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0042542	biological_process	response to hydrogen peroxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0043177	molecular_function	organic acid binding
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0071682	cellular_component	endocytic vesicle lumen
A	0072562	cellular_component	blood microparticle
A	0098869	biological_process	cellular oxidant detoxification
C	0004601	molecular_function	peroxidase activity
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005829	cellular_component	cytosol
C	0005833	cellular_component	hemoglobin complex
C	0015670	biological_process	carbon dioxide transport
C	0015671	biological_process	oxygen transport
C	0016020	cellular_component	membrane
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0030185	biological_process	nitric oxide transport
C	0031720	molecular_function	haptoglobin binding
C	0031838	cellular_component	haptoglobin-hemoglobin complex
C	0042542	biological_process	response to hydrogen peroxide
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0043177	molecular_function	organic acid binding
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0071682	cellular_component	endocytic vesicle lumen
C	0072562	cellular_component	blood microparticle
C	0098869	biological_process	cellular oxidant detoxification
E	0004601	molecular_function	peroxidase activity
E	0005344	molecular_function	oxygen carrier activity
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0005833	cellular_component	hemoglobin complex
E	0014070	biological_process	response to organic cyclic compound
E	0015670	biological_process	carbon dioxide transport
E	0015671	biological_process	oxygen transport
E	0019825	molecular_function	oxygen binding
E	0020037	molecular_function	heme binding
E	0031720	molecular_function	haptoglobin binding
E	0031721	molecular_function	hemoglobin alpha binding
E	0031838	cellular_component	haptoglobin-hemoglobin complex
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0043177	molecular_function	organic acid binding
E	0044877	molecular_function	protein-containing complex binding
E	0046872	molecular_function	metal ion binding
E	0072562	cellular_component	blood microparticle
E	0098869	biological_process	cellular oxidant detoxification
F	0004601	molecular_function	peroxidase activity
F	0005344	molecular_function	oxygen carrier activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0005833	cellular_component	hemoglobin complex
F	0014070	biological_process	response to organic cyclic compound
F	0015670	biological_process	carbon dioxide transport
F	0015671	biological_process	oxygen transport
F	0019825	molecular_function	oxygen binding
F	0020037	molecular_function	heme binding
F	0031720	molecular_function	haptoglobin binding
F	0031721	molecular_function	hemoglobin alpha binding
F	0031838	cellular_component	haptoglobin-hemoglobin complex
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0043177	molecular_function	organic acid binding
F	0044877	molecular_function	protein-containing complex binding
F	0046872	molecular_function	metal ion binding
F	0072562	cellular_component	blood microparticle
F	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE HEM A 142

Chain	Residue
A	TYR42
A	LEU101
A	LEU136
A	CMO143
A	PHE43
A	HIS45
A	HIS58
A	LYS61
A	HIS87
A	LEU91
A	VAL93
A	PHE98

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CMO A 143

Chain	Residue
A	HIS58
A	HEM142

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE HEM E 147

Chain	Residue
E	THR38
E	PHE41
E	PHE42
E	HIS63
E	LYS66
E	SER70
E	HIS92
E	LEU96
E	ASN102
E	PHE103
E	LEU106
E	LEU141
E	CMO148

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CMO E 148

Chain	Residue
E	HIS63
E	VAL67
E	HEM147

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEM C 142

Chain	Residue
A	ALA12
A	LYS16
C	TYR42
C	PHE43
C	HIS45
C	HIS58
C	LYS61
C	HIS87
C	LEU91
C	VAL93
C	PHE98
C	LEU101
C	LEU136
C	CMO143

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CMO C 143

Chain	Residue
C	HIS58
C	HEM142

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE HEM F 147

Chain	Residue
F	THR38
F	PHE41
F	PHE42
F	HIS63
F	LYS66
F	SER70
F	HIS92
F	LEU96
F	ASN102
F	PHE103
F	LEU106
F	LEU141
F	CMO148

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CMO F 148

Chain	Residue
F	HIS63
F	VAL67
F	HEM147

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: distal binding residue => ECO:0000250\|UniProtKB:P80044

Chain	Residue	Details
E	GLY64
F	GLY64

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: proximal binding residue => ECO:0000269\|PubMed:9665850, ECO:0007744\|PDB:1A9W

Chain	Residue	Details
E	CYS93
F	CYS93

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
E	LEU14
A	ARG92
A	VAL107
A	LEU109
A	HIS122
A	THR134
C	ASN9
C	TRP14
C	GLY25
C	GLU30
C	PHE46
E	PRO51
C	LEU48
C	ALA53
C	LYS56
C	LYS60
C	ARG92
C	VAL107
C	LEU109
C	HIS122
C	THR134
F	LEU14
F	PRO51
A	PHE46
A	LEU48
A	ALA53
A	LYS56
A	LYS60

site_id	SWS_FT_FI4
Number of Residues	10
Details	SITE: Not glycated => ECO:0000269\|PubMed:7358733

Chain	Residue	Details
A	ALA12
C	LEU100
A	GLY57
A	LYS61
A	LEU91
A	LEU100
C	ALA12
C	GLY57
C	LYS61
C	LEU91

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	PRO4
A	PHE36
A	HIS50
C	PRO4
C	PHE36
C	HIS50

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P01942

Chain	Residue	Details
A	THR8
A	VAL17
A	THR41
C	THR8
C	VAL17
C	THR41

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	ASN9
C	ASN9

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P01942

Chain	Residue	Details
A	ALA12
C	ALA12

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	GLY25
C	GLY25

site_id	SWS_FT_FI10
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P01942

Chain	Residue	Details
A	HIS103
A	LEU125
A	VAL132
A	LYS139
C	HIS103
C	LEU125
C	VAL132
C	LYS139

site_id	SWS_FT_FI11
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P01942

Chain	Residue	Details
A	LEU109
A	VAL135
A	SER138
C	LEU109
C	VAL135
C	SER138

site_id	SWS_FT_FI12
Number of Residues	6
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269\|PubMed:7358733

Chain	Residue	Details
A	THR8
A	VAL17
A	THR41
C	THR8
C	VAL17
C	THR41

site_id	SWS_FT_FI13
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269\|PubMed:7358733

Chain	Residue	Details
A	VAL62
C	VAL62

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)