1A95
XPRTASE FROM E. COLI COMPLEXED WITH MG:CPRPP AND GUANINE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0032265 | biological_process | XMP salvage |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| A | 0097216 | molecular_function | guanosine tetraphosphate binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0032265 | biological_process | XMP salvage |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0097216 | molecular_function | guanosine tetraphosphate binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0032263 | biological_process | GMP salvage |
| C | 0032264 | biological_process | IMP salvage |
| C | 0032265 | biological_process | XMP salvage |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051289 | biological_process | protein homotetramerization |
| C | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| C | 0097216 | molecular_function | guanosine tetraphosphate binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0000310 | molecular_function | xanthine phosphoribosyltransferase activity |
| D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0032263 | biological_process | GMP salvage |
| D | 0032264 | biological_process | IMP salvage |
| D | 0032265 | biological_process | XMP salvage |
| D | 0032991 | cellular_component | protein-containing complex |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051289 | biological_process | protein homotetramerization |
| D | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| D | 0097216 | molecular_function | guanosine tetraphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG C 307 |
| Chain | Residue |
| C | PCP302 |
| C | HOH533 |
| C | HOH534 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 308 |
| Chain | Residue |
| B | PCP301 |
| B | HOH535 |
| B | HOH536 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PCP B 301 |
| Chain | Residue |
| B | ARG69 |
| B | ASP88 |
| B | ASP89 |
| B | LEU90 |
| B | ASP92 |
| B | THR93 |
| B | GLY94 |
| B | GLY95 |
| B | THR96 |
| B | GUN304 |
| B | MG308 |
| B | HOH466 |
| B | HOH535 |
| B | HOH536 |
| B | SER36 |
| B | ARG37 |
| B | GLY38 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE PCP C 302 |
| Chain | Residue |
| C | ARG37 |
| C | GLY38 |
| C | ARG69 |
| C | ASP88 |
| C | ASP89 |
| C | LEU90 |
| C | ASP92 |
| C | THR93 |
| C | GLY94 |
| C | GLY95 |
| C | THR96 |
| C | GUN303 |
| C | MG307 |
| C | HOH421 |
| C | HOH453 |
| C | HOH463 |
| C | HOH487 |
| C | HOH533 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GUN C 303 |
| Chain | Residue |
| C | ASP92 |
| C | LYS115 |
| C | TRP134 |
| C | ILE135 |
| C | PCP302 |
| C | HOH424 |
| C | HOH487 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GUN B 304 |
| Chain | Residue |
| B | LEU90 |
| B | ASP92 |
| B | LYS115 |
| B | TRP134 |
| B | ILE135 |
| B | PCP301 |
| B | HOH435 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BO3 D 305 |
| Chain | Residue |
| B | ASN67 |
| D | VAL35 |
| D | SER36 |
| D | ARG37 |
| D | GLY38 |
| D | ASP88 |
| D | HOH422 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BO3 A 306 |
| Chain | Residue |
| A | VAL35 |
| A | SER36 |
| A | ARG37 |
| A | GLY38 |
| A | ASP88 |
| A | HOH471 |
| C | ASN67 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. FIVIDDLVDTGgT |
| Chain | Residue | Details |
| A | PHE84-THR96 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:9743633, ECO:0007744|PDB:1A95 |
| Chain | Residue | Details |
| A | ARG37 | |
| A | ASP88 | |
| B | ARG37 | |
| B | ASP88 | |
| C | ARG37 | |
| C | ASP88 | |
| D | ARG37 | |
| D | ASP88 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9743633, ECO:0007744|PDB:1A97 |
| Chain | Residue | Details |
| A | ARG69 | |
| A | TRP134 | |
| B | ARG69 | |
| B | TRP134 | |
| C | ARG69 | |
| C | TRP134 | |
| D | ARG69 | |
| D | TRP134 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9100006 |
| Chain | Residue | Details |
| A | ASP89 | |
| B | ASP89 | |
| C | ASP89 | |
| D | ASP89 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9743633, ECO:0007744|PDB:1A96 |
| Chain | Residue | Details |
| A | ASP92 | |
| A | ILE135 | |
| B | ASP92 | |
| B | ILE135 | |
| C | ASP92 | |
| C | ILE135 | |
| D | ASP92 | |
| D | ILE135 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | a catalytic site defined by CSA, PubMed 9743633, 10360366 |
| Chain | Residue | Details |
| A | ASP88 | |
| A | ASP89 | |
| A | ASP92 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 391 |
| Chain | Residue | Details |
| A | ASP88 | electrostatic stabiliser |
| A | ASP89 | electrostatic stabiliser |
| A | ASP92 | proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 391 |
| Chain | Residue | Details |
| B | ASP88 | electrostatic stabiliser |
| B | ASP89 | electrostatic stabiliser |
| B | ASP92 | proton shuttle (general acid/base) |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 391 |
| Chain | Residue | Details |
| C | ASP88 | electrostatic stabiliser |
| C | ASP89 | electrostatic stabiliser |
| C | ASP92 | proton shuttle (general acid/base) |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 391 |
| Chain | Residue | Details |
| D | ASP88 | electrostatic stabiliser |
| D | ASP89 | electrostatic stabiliser |
| D | ASP92 | proton shuttle (general acid/base) |
