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1A5E

SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, 18 STRUCTURES

Functional Information from GO Data
ChainGOidnamespacecontents
A0001953biological_processnegative regulation of cell-matrix adhesion
A0003723molecular_functionRNA binding
A0004861molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0007049biological_processcell cycle
A0007265biological_processRas protein signal transduction
A0008285biological_processnegative regulation of cell population proliferation
A0019901molecular_functionprotein kinase binding
A0030308biological_processnegative regulation of cell growth
A0032088biological_processnegative regulation of NF-kappaB transcription factor activity
A0034393biological_processpositive regulation of smooth muscle cell apoptotic process
A0035985cellular_componentsenescence-associated heterochromatin focus
A0042326biological_processnegative regulation of phosphorylation
A0045736biological_processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
A0045892biological_processnegative regulation of DNA-templated transcription
A0051059molecular_functionNF-kappaB binding
A0051726biological_processregulation of cell cycle
A0090398biological_processcellular senescence
A0090399biological_processreplicative senescence
A2000045biological_processregulation of G1/S transition of mitotic cell cycle
A2000111biological_processpositive regulation of macrophage apoptotic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
AMET1

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:12529334
ChainResidueDetails
ASER7
ASER8
ASER140
ASER152

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PDB entries from 2024-04-17

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