1A37

14-3-3 PROTEIN ZETA BOUND TO PS-RAF259 PEPTIDE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006468	biological_process	protein phosphorylation
A	0007165	biological_process	signal transduction
A	0042470	cellular_component	melanosome
A	0050815	molecular_function	phosphoserine residue binding
A	0070372	biological_process	regulation of ERK1 and ERK2 cascade
A	0140311	molecular_function	protein sequestering activity
B	0005737	cellular_component	cytoplasm
B	0006468	biological_process	protein phosphorylation
B	0007165	biological_process	signal transduction
B	0042470	cellular_component	melanosome
B	0050815	molecular_function	phosphoserine residue binding
B	0070372	biological_process	regulation of ERK1 and ERK2 cascade
B	0140311	molecular_function	protein sequestering activity

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG41-VAL51

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site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS

Chain	Residue	Details
A	TYR212-SER230

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Interaction with phosphoserine on interacting protein => ECO:0000269|PubMed:18550856, ECO:0000269|PubMed:9632691

Chain	Residue	Details
A	ARG56
A	ARG127
B	ARG56
B	ARG127

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P63104

Chain	Residue	Details
A	MET1
B	MET1

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P63104

Chain	Residue	Details
A	LYS3
A	LYS68
B	LYS3
B	LYS68

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:P63104

Chain	Residue	Details
A	SER58
B	SER58

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P63104

Chain	Residue	Details
A	SER184
A	SER212
B	SER184
B	SER212

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P63102

Chain	Residue	Details
A	SER212
B	SER212

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site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by CK1 => ECO:0000250|UniProtKB:P63104

Chain	Residue	Details
A	THR232
B	THR232

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