1A2O
STRUCTURAL BASIS FOR METHYLESTERASE CHEB REGULATION BY A PHOSPHORYLATION-ACTIVATED DOMAIN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000156 | molecular_function | phosphorelay response regulator activity |
| A | 0000160 | biological_process | phosphorelay signal transduction system |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006935 | biological_process | chemotaxis |
| A | 0007165 | biological_process | signal transduction |
| A | 0008984 | molecular_function | protein-glutamate methylesterase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0050568 | molecular_function | protein-glutamine glutaminase activity |
| B | 0000156 | molecular_function | phosphorelay response regulator activity |
| B | 0000160 | biological_process | phosphorelay signal transduction system |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006935 | biological_process | chemotaxis |
| B | 0007165 | biological_process | signal transduction |
| B | 0008984 | molecular_function | protein-glutamate methylesterase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0050568 | molecular_function | protein-glutamine glutaminase activity |
Functional Information from PDB Data
| site_id | ESE |
| Number of Residues | 3 |
| Details | ESTERASE CATALYTIC TRIAD |
| Chain | Residue |
| A | SER164 |
| A | HIS190 |
| A | ASP286 |
| site_id | PON |
| Number of Residues | 1 |
| Details | PHOSPHORYLATION SITE |
| Chain | Residue |
| A | ASP56 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 234 |
| Details | Domain: {"description":"Response regulatory","evidences":[{"source":"HAMAP-Rule","id":"MF_00099","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 384 |
| Details | Domain: {"description":"CheB-type methylesterase","evidences":[{"source":"HAMAP-Rule","id":"MF_00099","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00099","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7608974","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"4-aspartylphosphate","evidences":[{"source":"HAMAP-Rule","id":"MF_00099","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9465023","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1chd |
| Chain | Residue | Details |
| A | ASP286 | |
| A | SER164 | |
| A | MET283 | |
| A | THR165 | |
| A | HIS190 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1chd |
| Chain | Residue | Details |
| B | ASP286 | |
| B | SER164 | |
| B | MET283 | |
| B | THR165 | |
| B | HIS190 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 337 |
| Chain | Residue | Details |
| A | SER164 | activator, covalently attached, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | THR165 | electrostatic stabiliser, hydrogen bond donor |
| A | HIS190 | activator, electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor |
| A | MET283 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP286 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 337 |
| Chain | Residue | Details |
| B | SER164 | activator, covalently attached, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| B | THR165 | electrostatic stabiliser, hydrogen bond donor |
| B | HIS190 | activator, electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor |
| B | MET283 | electrostatic stabiliser, hydrogen bond donor |
| B | ASP286 | electrostatic stabiliser, hydrogen bond acceptor |
