1A29

CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:2 COMPLEX)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000922	cellular_component	spindle pole
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0019904	molecular_function	protein domain specific binding
A	0030234	molecular_function	enzyme regulator activity
A	0032991	cellular_component	protein-containing complex
A	0046872	molecular_function	metal ion binding
A	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
A	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 149

Chain	Residue
A	ASP20
A	ASP22
A	ASP24
A	THR26
A	GLU31

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 150

Chain	Residue
A	GLU67
A	ASP56
A	ASP58
A	ASN60
A	THR62

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 151

Chain	Residue
A	ASP93
A	ASP95
A	ASN97
A	TYR99
A	GLU104

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 152

Chain	Residue
A	ASP129
A	ASP131
A	ASP133
A	GLN135
A	GLU140

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TFP A 153

Chain	Residue
A	ILE100
A	LEU105
A	MET124
A	GLU127
A	VAL136
A	PHE141
A	MET144
A	TFP154

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TFP A 154

Chain	Residue
A	GLU11
A	GLU14
A	ALA15
A	MET109
A	GLU114
A	LEU116
A	GLU120
A	TFP153

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
A	ASP20-LEU32
A	ASP56-PHE68
A	ASP93-LEU105
A	ASP129-PHE141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448

Chain	Residue	Details
A	LYS21
A	PHE68
A	LYS94
A	GLY96
A	GLY98
A	ILE100
A	LEU105
A	ILE130
A	GLY132
A	GLY134
A	VAL136
A	GLY23
A	PHE141
A	GLY25
A	ILE27
A	LEU32
A	ALA57
A	GLY59
A	GLY61
A	ILE63

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7356670

Chain	Residue	Details
A	ASP2

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
A	ASP22

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29

Chain	Residue	Details
A	GLU45

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
A	GLU82
A	ALA102

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
A	ASP95

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
A	ILE100
A	GLU139

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
A	ASN111

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
A	LEU116

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:9716384

Chain	Residue	Details
A	ASP22

---