1A1Q

HEPATITIS C VIRUS NS3 PROTEINASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0019087	biological_process	transformation of host cell by virus
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity
B	0019087	biological_process	transformation of host cell by virus
C	0006508	biological_process	proteolysis
C	0008236	molecular_function	serine-type peptidase activity
C	0019087	biological_process	transformation of host cell by virus

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ZN C 901

Chain	Residue
C	CYS97

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000269|PubMed:8861916

Chain	Residue	Details
A	HIS57
A	ASP81
B	HIS57
B	ASP81
C	HIS57
C	ASP81

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site_id	SWS_FT_FI2
Number of Residues	3
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000269|PubMed:8861916, ECO:0000269|PubMed:9568891

Chain	Residue	Details
A	SER139
B	SER139
C	SER139

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000269|PubMed:10366511, ECO:0000269|PubMed:8861916, ECO:0000269|PubMed:9568891

Chain	Residue	Details
A	CYS97
A	CYS99
B	CYS97
B	CYS99
C	CYS97
C	CYS99

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site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000269|PubMed:10366511, ECO:0000269|PubMed:8861916

Chain	Residue	Details
A	CYS145
A	HIS149
B	CYS145
B	HIS149
C	CYS145
C	HIS149

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1rgq

Chain	Residue	Details
A	ASP81
A	SER139
A	GLY137
A	HIS57

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site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1rgq

Chain	Residue	Details
B	ASP81
B	SER139
B	GLY137
B	HIS57

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site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1rgq

Chain	Residue	Details
C	ASP81
C	SER139
C	GLY137
C	HIS57

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