1A03

THE THREE-DIMENSIONAL STRUCTURE OF CA2+-BOUND CALCYCLIN: IMPLICATIONS FOR CA2+-SIGNAL TRANSDUCTION BY S100 PROTEINS, NMR, 20 STRUCTURES

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0044548	molecular_function	S100 protein binding
A	0046872	molecular_function	metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0009898	cellular_component	cytoplasmic side of plasma membrane
B	0044548	molecular_function	S100 protein binding
B	0046872	molecular_function	metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0048471	cellular_component	perinuclear region of cytoplasm

Functional Information from PDB Data

site_id	L2
Number of Residues	12
Details	SECOND PREDICTED CA2+ BINDING LOOP.

Chain	Residue
A	ASP61
A	ARG62
A	ASN63
A	LYS64
A	ASP65
A	GLN66
A	GLU67
A	VAL68
A	ASN69
A	PHE70
A	GLN71
A	GLU72

---

site_id	L2'
Number of Residues	12
Details	SECOND PREDICTED CA2+ BINDING LOOP.

Chain	Residue
B	ASP61
B	ARG62
B	ASN63
B	LYS64
B	ASP65
B	GLN66
B	GLU67
B	VAL68
B	ASN69
B	PHE70
B	GLN71
B	GLU72

---

site_id	LI
Number of Residues	14
Details	FIRST PREDICTED CA2+ BINDING LOOP.

Chain	Residue
A	SER20
A	LEU29
A	SER30
A	LYS31
A	LYS32
A	GLU33
A	GLY21
A	LYS22
A	GLU23
A	GLY24
A	ASP25
A	LYS26
A	HIS27
A	THR28

---

site_id	LI'
Number of Residues	14
Details	FIRST PREDICTED CA2+ BINDING LOOP.

Chain	Residue
B	SER20
B	GLY21
B	LYS22
B	GLU23
B	GLY24
B	ASP25
B	LYS26
B	HIS27
B	THR28
B	LEU29
B	SER30
B	LYS31
B	LYS32
B	GLU33

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DRNKDQEVNfqEY

Chain	Residue	Details
A	ASP61-TYR73

---

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. LMddLDrnkDqevNFqEYitFL

Chain	Residue	Details
A	LEU56-LEU77

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	70
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P06703","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P06703","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P14069","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---