16PK
PHOSPHOGLYCERATE KINASE FROM TRYPANOSOMA BRUCEI BISUBSTRATE ANALOG
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004618 | molecular_function | phosphoglycerate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0020015 | cellular_component | glycosome |
| A | 0043531 | molecular_function | ADP binding |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE BIS A 499 |
| Chain | Residue |
| A | GLY217 |
| A | PRO340 |
| A | GLY342 |
| A | VAL343 |
| A | GLU345 |
| A | GLY397 |
| A | GLY398 |
| A | GLY399 |
| A | HOH505 |
| A | HOH514 |
| A | HOH523 |
| A | ALA218 |
| A | HOH571 |
| A | HOH673 |
| A | HOH766 |
| A | HOH768 |
| A | HOH779 |
| A | HOH781 |
| A | HOH799 |
| A | HOH872 |
| A | HOH874 |
| A | HOH902 |
| A | LYS223 |
| A | HOH981 |
| A | HOH1020 |
| A | HOH1032 |
| A | HOH1034 |
| A | HOH1037 |
| A | GLY241 |
| A | ALA242 |
| A | TYR245 |
| A | ALA314 |
| A | LEU315 |
| A | GLY339 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE EPE A 430 |
| Chain | Residue |
| A | LYS49 |
| A | THR52 |
| A | GLU53 |
| A | GLN251 |
| A | GLY252 |
| A | TYR253 |
| A | ALA296 |
| A | GLU345 |
| A | MET346 |
| A | VAL347 |
| A | PRO348 |
| A | HOH567 |
| A | HOH676 |
| A | HOH809 |
| A | HOH871 |
Functional Information from PROSITE/UniProt
| site_id | PS00111 |
| Number of Residues | 11 |
| Details | PGLYCERATE_KINASE Phosphoglycerate kinase signature. KVLIRvDfNVP |
| Chain | Residue | Details |
| A | LYS18-PRO28 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P00558","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9000079","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"13PK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9000079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9642090","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"13PK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q7SIB7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 13pk |
| Chain | Residue | Details |
| A | GLY376 | |
| A | ARG39 | |
| A | LYS219 | |
| A | GLY399 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 40 |
| Chain | Residue | Details |
| A | ARG39 | electrostatic stabiliser, hydrogen bond donor |
| A | LYS219 | electrostatic stabiliser, hydrogen bond donor |
| A | GLY376 | electrostatic stabiliser, hydrogen bond donor |
| A | GLY399 | electrostatic stabiliser, hydrogen bond donor |
