13LD
Deuterated alanine racemase from Geobacillus stearothermophilus
Functional Information from PROSITE/UniProt
| site_id | PS00395 |
| Number of Residues | 11 |
| Details | ALANINE_RACEMASE Alanine racemase pyridoxal-phosphate attachment site. AVvKANAYGHG |
| Chain | Residue | Details |
| A | ALA36-GLY46 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor; specific for D-alanine","evidences":[{"source":"PubMed","id":"10502689","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15807525","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor; specific for L-alanine","evidences":[{"source":"PubMed","id":"10502689","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15807525","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11886871","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"11886871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15807525","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9063881","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"10079072","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11886871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12741835","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15807525","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2000","submissionDatabase":"PDB data bank","title":"Crystal structure of alanine racemase in complex with D-alanine phosphonate.","authors":["Stamper G.F.","Ringe D."]}}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 213 |
| Chain | Residue | Details |
| A | LLP39 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | GLU144 | electrostatic stabiliser |
| A | ASN174 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| A | LEU227 | electrostatic stabiliser, hydrogen bond donor |
| A | THR273 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | LEU319 | electrostatic stabiliser |
| A | GLY321 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 213 |
| Chain | Residue | Details |
| B | LLP39 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| B | GLU144 | electrostatic stabiliser |
| B | ASN174 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| B | LEU227 | electrostatic stabiliser, hydrogen bond donor |
| B | THR273 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | LEU319 | electrostatic stabiliser |
| B | GLY321 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA3 |
| Number of Residues | 7 |
| Details | M-CSA 213 |
| Chain | Residue | Details |
| C | LLP39 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| C | GLU144 | electrostatic stabiliser |
| C | ASN174 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| C | LEU227 | electrostatic stabiliser, hydrogen bond donor |
| C | THR273 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | LEU319 | electrostatic stabiliser |
| C | GLY321 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA4 |
| Number of Residues | 7 |
| Details | M-CSA 213 |
| Chain | Residue | Details |
| D | LLP39 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| D | GLU144 | electrostatic stabiliser |
| D | ASN174 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| D | LEU227 | electrostatic stabiliser, hydrogen bond donor |
| D | THR273 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| D | LEU319 | electrostatic stabiliser |
| D | GLY321 | electrostatic stabiliser, hydrogen bond acceptor |
