13CO

Cryo-EM structure of an intact human acetylcholinesterase (T-form) tetramer in complex with ColQ

Functional Information from PROSITE/UniProt

site_id	PS00122
Number of Residues	16
Details	CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGdptsVtLfGeSAG

Chain	Residue	Details
A	PHE190-GLY205

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site_id	PS00941
Number of Residues	11
Details	CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNVWtP

Chain	Residue	Details
A	GLU94-PRO104

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PDB","id":"4EY5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PDB","id":"4BDT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"4EY6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23035744","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11053835","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20408548","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23035744","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23679855","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1F8U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X8B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EY8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23035744","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EY8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	4
Details	Lipidation: {"description":"GPI-anchor amidated glycine","evidences":[{"source":"PubMed","id":"15489334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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