12SA

Crystal Structure of the Catalytic Subunit of the Circadian Regulator Casein Kinase 2 from Neurospora crassa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0005956	cellular_component	protein kinase CK2 complex
A	0006974	biological_process	DNA damage response
A	0016301	molecular_function	kinase activity
A	0051726	biological_process	regulation of cell cycle
A	0106310	molecular_function	protein serine kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005634	cellular_component	nucleus
B	0005829	cellular_component	cytosol
B	0005956	cellular_component	protein kinase CK2 complex
B	0006974	biological_process	DNA damage response
B	0016301	molecular_function	kinase activity
B	0051726	biological_process	regulation of cell cycle
B	0106310	molecular_function	protein serine kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0005956	cellular_component	protein kinase CK2 complex
C	0006974	biological_process	DNA damage response
C	0016301	molecular_function	kinase activity
C	0051726	biological_process	regulation of cell cycle
C	0106310	molecular_function	protein serine kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005634	cellular_component	nucleus
D	0005829	cellular_component	cytosol
D	0005956	cellular_component	protein kinase CK2 complex
D	0006974	biological_process	DNA damage response
D	0016301	molecular_function	kinase activity
D	0051726	biological_process	regulation of cell cycle
D	0106310	molecular_function	protein serine kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0005634	cellular_component	nucleus
E	0005829	cellular_component	cytosol
E	0005956	cellular_component	protein kinase CK2 complex
E	0006974	biological_process	DNA damage response
E	0016301	molecular_function	kinase activity
E	0051726	biological_process	regulation of cell cycle
E	0106310	molecular_function	protein serine kinase activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0005634	cellular_component	nucleus
F	0005829	cellular_component	cytosol
F	0005956	cellular_component	protein kinase CK2 complex
F	0006974	biological_process	DNA damage response
F	0016301	molecular_function	kinase activity
F	0051726	biological_process	regulation of cell cycle
F	0106310	molecular_function	protein serine kinase activity

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGKYSEVFeGinvvnyqk..........CVIK

Chain	Residue	Details
A	ILE40-LYS63

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI

Chain	Residue	Details
A	ILE147-ILE159

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	855
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	54
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---