11YZ

Cryo EM Structure of GTP cyclohydrolase 1 (FolE) from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003934	molecular_function	GTP cyclohydrolase I activity
A	0005737	cellular_component	cytoplasm
A	0006729	biological_process	tetrahydrobiopterin biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0008270	molecular_function	zinc ion binding
A	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0003934	molecular_function	GTP cyclohydrolase I activity
B	0005737	cellular_component	cytoplasm
B	0006729	biological_process	tetrahydrobiopterin biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0008270	molecular_function	zinc ion binding
B	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0003934	molecular_function	GTP cyclohydrolase I activity
C	0005737	cellular_component	cytoplasm
C	0006729	biological_process	tetrahydrobiopterin biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0008270	molecular_function	zinc ion binding
C	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0003934	molecular_function	GTP cyclohydrolase I activity
D	0005737	cellular_component	cytoplasm
D	0006729	biological_process	tetrahydrobiopterin biosynthetic process
D	0006730	biological_process	one-carbon metabolic process
D	0008270	molecular_function	zinc ion binding
D	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0003934	molecular_function	GTP cyclohydrolase I activity
E	0005737	cellular_component	cytoplasm
E	0006729	biological_process	tetrahydrobiopterin biosynthetic process
E	0006730	biological_process	one-carbon metabolic process
E	0008270	molecular_function	zinc ion binding
E	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0003934	molecular_function	GTP cyclohydrolase I activity
F	0005737	cellular_component	cytoplasm
F	0006729	biological_process	tetrahydrobiopterin biosynthetic process
F	0006730	biological_process	one-carbon metabolic process
F	0008270	molecular_function	zinc ion binding
F	0046654	biological_process	tetrahydrofolate biosynthetic process
G	0003934	molecular_function	GTP cyclohydrolase I activity
G	0005737	cellular_component	cytoplasm
G	0006729	biological_process	tetrahydrobiopterin biosynthetic process
G	0006730	biological_process	one-carbon metabolic process
G	0008270	molecular_function	zinc ion binding
G	0046654	biological_process	tetrahydrofolate biosynthetic process
H	0003934	molecular_function	GTP cyclohydrolase I activity
H	0005737	cellular_component	cytoplasm
H	0006729	biological_process	tetrahydrobiopterin biosynthetic process
H	0006730	biological_process	one-carbon metabolic process
H	0008270	molecular_function	zinc ion binding
H	0046654	biological_process	tetrahydrofolate biosynthetic process
I	0003934	molecular_function	GTP cyclohydrolase I activity
I	0005737	cellular_component	cytoplasm
I	0006729	biological_process	tetrahydrobiopterin biosynthetic process
I	0006730	biological_process	one-carbon metabolic process
I	0008270	molecular_function	zinc ion binding
I	0046654	biological_process	tetrahydrofolate biosynthetic process
J	0003934	molecular_function	GTP cyclohydrolase I activity
J	0005737	cellular_component	cytoplasm
J	0006729	biological_process	tetrahydrobiopterin biosynthetic process
J	0006730	biological_process	one-carbon metabolic process
J	0008270	molecular_function	zinc ion binding
J	0046654	biological_process	tetrahydrofolate biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00859
Number of Residues	17
Details	GTP_CYCLOHYDROL_1_1 GTP cyclohydrolase I signature 1. ELVlvKEIpmyStCEHH

Chain	Residue	Details
A	GLU77-HIS93

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site_id	PS00860
Number of Residues	11
Details	GTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. AkRpQVQERLT

Chain	Residue	Details
A	ALA127-THR137

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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