10TC

Structure of WDR5 bound to RbBP5 (D376N)

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV

Chain	Residue	Details
A	LEU102-VAL116
A	ILE144-VAL158
A	ILE186-THR200
A	ILE274-LEU288

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	156
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	164
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	160
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	156
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	164
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	160
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	136
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	16
Details	Site: {"description":"Important for interaction with histone H3"}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI10
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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