Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

10MT

C2 symmetry expanded and subtracted 20S Proteasome, Blm10, Fub1 Complex Halfmer

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0005575	cellular_component	cellular_component
a	0008150	biological_process	biological_process
a	0070628	molecular_function	proteasome binding
A	0000502	cellular_component	proteasome complex
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0005575	cellular_component	cellular_component
b	0008150	biological_process	biological_process
b	0070628	molecular_function	proteasome binding
B	0000502	cellular_component	proteasome complex
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0034515	cellular_component	proteasome storage granule
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0000502	cellular_component	proteasome complex
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0034515	cellular_component	proteasome storage granule
C	0042175	cellular_component	nuclear outer membrane-endoplasmic reticulum membrane network
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
CA	0005515	molecular_function	protein binding
CA	0005634	cellular_component	nucleus
CA	0005737	cellular_component	cytoplasm
CA	0006281	biological_process	DNA repair
CA	0006974	biological_process	DNA damage response
CA	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
CA	0016504	molecular_function	peptidase activator activity
CA	0034515	cellular_component	proteasome storage granule
CA	0043248	biological_process	proteasome assembly
CA	0061136	biological_process	regulation of proteasomal protein catabolic process
CA	0070628	molecular_function	proteasome binding
CA	1902906	biological_process	proteasome storage granule assembly
CA	1990236	biological_process	proteasome core complex import into nucleus
D	0000502	cellular_component	proteasome complex
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0034515	cellular_component	proteasome storage granule
D	0042175	cellular_component	nuclear outer membrane-endoplasmic reticulum membrane network
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0034515	cellular_component	proteasome storage granule
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0003674	molecular_function	molecular_function
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0034515	cellular_component	proteasome storage granule
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0000502	cellular_component	proteasome complex
G	0003729	molecular_function	mRNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0034515	cellular_component	proteasome storage granule
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0000502	cellular_component	proteasome complex
H	0004175	molecular_function	endopeptidase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
H	0019774	cellular_component	proteasome core complex, beta-subunit complex
H	0034515	cellular_component	proteasome storage granule
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0004175	molecular_function	endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
I	0019774	cellular_component	proteasome core complex, beta-subunit complex
I	0034515	cellular_component	proteasome storage granule
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0061133	molecular_function	endopeptidase activator activity
K	0000502	cellular_component	proteasome complex
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0005829	cellular_component	cytosol
K	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
K	0019774	cellular_component	proteasome core complex, beta-subunit complex
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0061133	molecular_function	endopeptidase activator activity
L	0000502	cellular_component	proteasome complex
L	0004175	molecular_function	endopeptidase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005777	cellular_component	peroxisome
L	0005829	cellular_component	cytosol
L	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
L	0019774	cellular_component	proteasome core complex, beta-subunit complex
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0080129	biological_process	proteasome core complex assembly
M	0000502	cellular_component	proteasome complex
M	0003674	molecular_function	molecular_function
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
M	0019774	cellular_component	proteasome core complex, beta-subunit complex
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0000502	cellular_component	proteasome complex
N	0003674	molecular_function	molecular_function
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
N	0019774	cellular_component	proteasome core complex, beta-subunit complex
N	0034515	cellular_component	proteasome storage granule
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0043248	biological_process	proteasome assembly

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdralSiFSPdGHifQVEYAleA

Chain	Residue	Details
C	TYR4-ALA26
E	TYR8-ALA30
A	TYR12-ALA34
G	TYR7-ALA29
F	TYR6-ALA28
B	TYR5-ALA27

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD

Chain	Residue	Details
C	VAL34-ASP81
L	LEU79-ASP126
H	MET23-ASP70
N	ILE45-ASP92
M	LEU32-ASP79
I	VAL33-ASP80
J	VAL13-ASP59
K	LEU5-ASP52

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9087403","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	39
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	35
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	39
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	38
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	84
Details	Region: {"description":"Bromodomain-like (BRDL)"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Motif: {"description":"YYX motif"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	8
Details	M-CSA 177

Chain	Residue	Details
F	LYS30	covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
F	LEU46	activator, steric locator
F	ALA48	activator
F	LYS62	activator, electrostatic stabiliser
F	GLY76	electrostatic stabiliser
F	GLY158	activator, electrostatic stabiliser
F	GLU195	activator, steric locator
F	SER198	activator, electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)