10MT
C2 symmetry expanded and subtracted 20S Proteasome, Blm10, Fub1 Complex Halfmer
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS00388 |
| Number of Residues | 23 |
| Details | PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdrgvStFSPeGRlfQVEYSleA |
| Chain | Residue | Details |
| E | TYR8-ALA30 | |
| A | TYR12-ALA34 | |
| G | TYR7-ALA29 | |
| B | TYR5-ALA27 | |
| C | TYR4-ALA26 | |
| F | TYR6-ALA28 |
| site_id | PS00854 |
| Number of Residues | 47 |
| Details | PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VAMtGkdCVAIACDlrlgsqslgvsnkfe.Kifhyghvflgit.GlaTD |
| Chain | Residue | Details |
| J | VAL13-ASP59 | |
| K | LEU5-ASP52 | |
| H | MET23-ASP70 | |
| M | LEU32-ASP79 | |
| I | VAL33-ASP80 | |
| N | ILE45-ASP92 | |
| L | LEU79-ASP126 | |
| C | VAL34-ASP81 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9087403","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"HEAT 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"HEAT 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"HEAT 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 84 |
| Details | Region: {"description":"Bromodomain-like (BRDL)"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Motif: {"description":"YYX motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 8 |
| Details | M-CSA 177 |
| Chain | Residue | Details |
| F | LYS30 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| F | LEU46 | activator, steric locator |
| F | ALA48 | activator |
| F | LYS62 | activator, electrostatic stabiliser |
| F | GLY76 | electrostatic stabiliser |
| F | GLY158 | activator, electrostatic stabiliser |
| F | GLU195 | activator, steric locator |
| F | SER198 | activator, electrostatic stabiliser |
