10EH

De novo assembled CBF3-CEN complex

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000022	biological_process	mitotic spindle elongation
a	0000775	cellular_component	chromosome, centromeric region
a	0000776	cellular_component	kinetochore
a	0000779	cellular_component	condensed chromosome, centromeric region
a	0000921	biological_process	septin ring assembly
a	0003677	molecular_function	DNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005816	cellular_component	spindle pole body
a	0005819	cellular_component	spindle
a	0007059	biological_process	chromosome segregation
a	0008301	molecular_function	DNA binding, bending
a	0019237	molecular_function	centromeric DNA binding
a	0031518	cellular_component	CBF3 complex
a	0051233	cellular_component	spindle midzone
a	0051382	biological_process	kinetochore assembly
A	0000022	biological_process	mitotic spindle elongation
A	0000775	cellular_component	chromosome, centromeric region
A	0000776	cellular_component	kinetochore
A	0000779	cellular_component	condensed chromosome, centromeric region
A	0000921	biological_process	septin ring assembly
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005816	cellular_component	spindle pole body
A	0005819	cellular_component	spindle
A	0007059	biological_process	chromosome segregation
A	0008301	molecular_function	DNA binding, bending
A	0019237	molecular_function	centromeric DNA binding
A	0031518	cellular_component	CBF3 complex
A	0051233	cellular_component	spindle midzone
A	0051382	biological_process	kinetochore assembly
b	0000775	cellular_component	chromosome, centromeric region
b	0000776	cellular_component	kinetochore
b	0000921	biological_process	septin ring assembly
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0006357	biological_process	regulation of transcription by RNA polymerase II
b	0007094	biological_process	mitotic spindle assembly checkpoint signaling
b	0008270	molecular_function	zinc ion binding
b	0008301	molecular_function	DNA binding, bending
b	0019237	molecular_function	centromeric DNA binding
b	0031518	cellular_component	CBF3 complex
b	0042802	molecular_function	identical protein binding
b	0051382	biological_process	kinetochore assembly
B	0000775	cellular_component	chromosome, centromeric region
B	0000776	cellular_component	kinetochore
B	0000921	biological_process	septin ring assembly
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0007094	biological_process	mitotic spindle assembly checkpoint signaling
B	0008270	molecular_function	zinc ion binding
B	0008301	molecular_function	DNA binding, bending
B	0019237	molecular_function	centromeric DNA binding
B	0031518	cellular_component	CBF3 complex
B	0042802	molecular_function	identical protein binding
B	0051382	biological_process	kinetochore assembly
c	0000775	cellular_component	chromosome, centromeric region
c	0000776	cellular_component	kinetochore
c	0000921	biological_process	septin ring assembly
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0006357	biological_process	regulation of transcription by RNA polymerase II
c	0007094	biological_process	mitotic spindle assembly checkpoint signaling
c	0008270	molecular_function	zinc ion binding
c	0008301	molecular_function	DNA binding, bending
c	0019237	molecular_function	centromeric DNA binding
c	0031518	cellular_component	CBF3 complex
c	0042802	molecular_function	identical protein binding
c	0051382	biological_process	kinetochore assembly
C	0000775	cellular_component	chromosome, centromeric region
C	0000776	cellular_component	kinetochore
C	0000921	biological_process	septin ring assembly
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0007094	biological_process	mitotic spindle assembly checkpoint signaling
C	0008270	molecular_function	zinc ion binding
C	0008301	molecular_function	DNA binding, bending
C	0019237	molecular_function	centromeric DNA binding
C	0031518	cellular_component	CBF3 complex
C	0042802	molecular_function	identical protein binding
C	0051382	biological_process	kinetochore assembly
d	0000775	cellular_component	chromosome, centromeric region
d	0000776	cellular_component	kinetochore
d	0000921	biological_process	septin ring assembly
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0008301	molecular_function	DNA binding, bending
d	0031518	cellular_component	CBF3 complex
d	0051382	biological_process	kinetochore assembly
D	0000775	cellular_component	chromosome, centromeric region
D	0000776	cellular_component	kinetochore
D	0000921	biological_process	septin ring assembly
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0008301	molecular_function	DNA binding, bending
D	0031518	cellular_component	CBF3 complex
D	0051382	biological_process	kinetochore assembly
e	0000082	biological_process	G1/S transition of mitotic cell cycle
e	0000086	biological_process	G2/M transition of mitotic cell cycle
e	0000278	biological_process	mitotic cell cycle
e	0000409	biological_process	regulation of transcription by galactose
e	0000776	cellular_component	kinetochore
e	0000781	cellular_component	chromosome, telomeric region
e	0000921	biological_process	septin ring assembly
e	0003688	molecular_function	DNA replication origin binding
e	0004842	molecular_function	ubiquitin-protein transferase activity
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005737	cellular_component	cytoplasm
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
e	0007035	biological_process	vacuolar acidification
e	0007096	biological_process	regulation of exit from mitosis
e	0007346	biological_process	regulation of mitotic cell cycle
e	0008053	biological_process	mitochondrial fusion
e	0010458	biological_process	exit from mitosis
e	0010828	biological_process	positive regulation of D-glucose transmembrane transport
e	0012505	cellular_component	endomembrane system
e	0016567	biological_process	protein ubiquitination
e	0019005	cellular_component	SCF ubiquitin ligase complex
e	0030466	biological_process	silent mating-type cassette heterochromatin formation
e	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
e	0031509	biological_process	subtelomeric heterochromatin formation
e	0031518	cellular_component	CBF3 complex
e	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
e	0043254	biological_process	regulation of protein-containing complex assembly
e	0043291	cellular_component	RAVE complex
e	0045116	biological_process	protein neddylation
e	0051382	biological_process	kinetochore assembly
e	0061630	molecular_function	ubiquitin protein ligase activity
e	0065003	biological_process	protein-containing complex assembly
e	0070072	biological_process	vacuolar proton-transporting V-type ATPase complex assembly
e	0071406	biological_process	cellular response to methylmercury
e	0097602	molecular_function	cullin family protein binding
e	2000766	biological_process	negative regulation of cytoplasmic translation
E	0000082	biological_process	G1/S transition of mitotic cell cycle
E	0000086	biological_process	G2/M transition of mitotic cell cycle
E	0000278	biological_process	mitotic cell cycle
E	0000409	biological_process	regulation of transcription by galactose
E	0000776	cellular_component	kinetochore
E	0000781	cellular_component	chromosome, telomeric region
E	0000921	biological_process	septin ring assembly
E	0003688	molecular_function	DNA replication origin binding
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0007035	biological_process	vacuolar acidification
E	0007096	biological_process	regulation of exit from mitosis
E	0007346	biological_process	regulation of mitotic cell cycle
E	0008053	biological_process	mitochondrial fusion
E	0010458	biological_process	exit from mitosis
E	0010828	biological_process	positive regulation of D-glucose transmembrane transport
E	0012505	cellular_component	endomembrane system
E	0016567	biological_process	protein ubiquitination
E	0019005	cellular_component	SCF ubiquitin ligase complex
E	0030466	biological_process	silent mating-type cassette heterochromatin formation
E	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E	0031509	biological_process	subtelomeric heterochromatin formation
E	0031518	cellular_component	CBF3 complex
E	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
E	0043254	biological_process	regulation of protein-containing complex assembly
E	0043291	cellular_component	RAVE complex
E	0045116	biological_process	protein neddylation
E	0051382	biological_process	kinetochore assembly
E	0061630	molecular_function	ubiquitin protein ligase activity
E	0065003	biological_process	protein-containing complex assembly
E	0070072	biological_process	vacuolar proton-transporting V-type ATPase complex assembly
E	0071406	biological_process	cellular response to methylmercury
E	0097602	molecular_function	cullin family protein binding
E	2000766	biological_process	negative regulation of cytoplasmic translation
H	0000022	biological_process	mitotic spindle elongation
H	0000775	cellular_component	chromosome, centromeric region
H	0000776	cellular_component	kinetochore
H	0000779	cellular_component	condensed chromosome, centromeric region
H	0000921	biological_process	septin ring assembly
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005816	cellular_component	spindle pole body
H	0005819	cellular_component	spindle
H	0007059	biological_process	chromosome segregation
H	0008301	molecular_function	DNA binding, bending
H	0019237	molecular_function	centromeric DNA binding
H	0031518	cellular_component	CBF3 complex
H	0051233	cellular_component	spindle midzone
H	0051382	biological_process	kinetochore assembly
I	0000022	biological_process	mitotic spindle elongation
I	0000775	cellular_component	chromosome, centromeric region
I	0000776	cellular_component	kinetochore
I	0000779	cellular_component	condensed chromosome, centromeric region
I	0000921	biological_process	septin ring assembly
I	0003677	molecular_function	DNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005816	cellular_component	spindle pole body
I	0005819	cellular_component	spindle
I	0007059	biological_process	chromosome segregation
I	0008301	molecular_function	DNA binding, bending
I	0019237	molecular_function	centromeric DNA binding
I	0031518	cellular_component	CBF3 complex
I	0051233	cellular_component	spindle midzone
I	0051382	biological_process	kinetochore assembly
J	0000022	biological_process	mitotic spindle elongation
J	0000775	cellular_component	chromosome, centromeric region
J	0000776	cellular_component	kinetochore
J	0000779	cellular_component	condensed chromosome, centromeric region
J	0000921	biological_process	septin ring assembly
J	0003677	molecular_function	DNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005816	cellular_component	spindle pole body
J	0005819	cellular_component	spindle
J	0007059	biological_process	chromosome segregation
J	0008301	molecular_function	DNA binding, bending
J	0019237	molecular_function	centromeric DNA binding
J	0031518	cellular_component	CBF3 complex
J	0051233	cellular_component	spindle midzone
J	0051382	biological_process	kinetochore assembly

Functional Information from PROSITE/UniProt

site_id	PS00463
Number of Residues	30
Details	ZN2_CY6_FUNGAL_1 Zn(2)-C6 fungal-type DNA-binding domain signature. PCsvCTrrKvkCdrmip.......CgnCrkrgqdseC

Chain	Residue	Details
B	PRO13-CYS42

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	DNA binding: {"description":"Zn(2)-C6 fungal-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00227","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	118
Details	Region: {"description":"Interaction with the F-box domain of F-box proteins","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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