9T0D
Crystal structure of wild-type c-MET bound by glesatinib
This is a non-PDB format compatible entry.
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | DIAMOND BEAMLINE I04 |
| Synchrotron site | Diamond |
| Beamline | I04 |
| Temperature [K] | 100 |
| Detector technology | PIXEL |
| Collection date | 2024-10-07 |
| Detector | DECTRIS EIGER2 X 16M |
| Wavelength(s) | 0.95372 |
| Spacegroup name | P 1 21 1 |
| Unit cell lengths | 37.836, 42.144, 88.887 |
| Unit cell angles | 90.00, 92.34, 90.00 |
Refinement procedure
| Resolution | 23.790 - 1.196 |
| R-factor | 0.1996 |
| Rwork | 0.199 |
| R-free | 0.22130 |
| Structure solution method | MOLECULAR REPLACEMENT |
| RMSD bond length | 0.013 |
| RMSD bond angle | 1.230 |
| Data reduction software | autoPROC |
| Data scaling software | autoPROC |
| Phasing software | PHASER |
| Refinement software | BUSTER (2.11.8) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 88.810 | 1.300 |
| High resolution limit [Å] | 1.200 | 1.200 |
| Number of reflections | 68196 | 3410 |
| <I/σ(I)> | 11.6 | |
| Completeness [%] | 87.5 | |
| Redundancy | 3.1 | |
| CC(1/2) | 0.956 | 0.399 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION, SITTING DROP | 293 | 30% PEG8K, 0.2 M NaOAc, 0.1 M Na cacodylate pH 6.5 |
