9T08
Crystal structure of wild-type c-MET bound by sitravatinib.
This is a non-PDB format compatible entry.
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | DIAMOND BEAMLINE I04 |
| Synchrotron site | Diamond |
| Beamline | I04 |
| Temperature [K] | 100 |
| Detector technology | PIXEL |
| Collection date | 2024-11-18 |
| Detector | DECTRIS EIGER2 X 16M |
| Wavelength(s) | 0.95373 |
| Spacegroup name | P 1 21 1 |
| Unit cell lengths | 38.570, 42.434, 89.884 |
| Unit cell angles | 90.00, 90.72, 90.00 |
Refinement procedure
| Resolution | 44.940 - 1.462 |
| R-factor | 0.2138 |
| Rwork | 0.212 |
| R-free | 0.24250 |
| Structure solution method | MOLECULAR REPLACEMENT |
| RMSD bond length | 0.011 |
| RMSD bond angle | 0.970 |
| Data reduction software | autoPROC |
| Data scaling software | autoPROC |
| Phasing software | PHASER |
| Refinement software | BUSTER (2.11.8) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 44.940 | 1.640 |
| High resolution limit [Å] | 1.460 | 1.460 |
| Number of reflections | 25802 | 1290 |
| <I/σ(I)> | 7.8 | |
| Completeness [%] | 86.7 | |
| Redundancy | 3.2 | |
| CC(1/2) | 0.998 | 0.698 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION, SITTING DROP | 293 | 20% PEG4K, 10% isopropanol, 0.1 M Na-HEPES pH 7.5 |
