9WPB
Crystal structure of human transthyretin (TTR) with pryazole-based stabilizer
This is a non-PDB format compatible entry.
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | PAL/PLS BEAMLINE 11C |
| Synchrotron site | PAL/PLS |
| Beamline | 11C |
| Temperature [K] | 180 |
| Detector technology | PIXEL |
| Collection date | 2025-06-04 |
| Detector | DECTRIS PILATUS 6M |
| Wavelength(s) | 0.97942 |
| Spacegroup name | P 1 |
| Unit cell lengths | 43.948, 65.187, 84.665 |
| Unit cell angles | 90.03, 89.98, 89.99 |
Refinement procedure
| Resolution | 42.330 - 1.580 |
| R-factor | 0.1726 |
| Rwork | 0.172 |
| R-free | 0.17970 |
| Structure solution method | MOLECULAR REPLACEMENT |
| RMSD bond length | 0.007 |
| RMSD bond angle | 0.921 |
| Data reduction software | HKL-2000 |
| Data scaling software | HKL-2000 |
| Phasing software | PHENIX |
| Refinement software | PHENIX (1.20.1_4487) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 50.000 | 1.610 |
| High resolution limit [Å] | 1.580 | 1.580 |
| Number of reflections | 113158 | 5140 |
| <I/σ(I)> | 26.5 | 5.7 |
| Completeness [%] | 88.0 | 80.8 |
| Redundancy | 3.8 | 3.6 |
| CC(1/2) | 0.989 | 0.924 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION, HANGING DROP | 291 | 0.2M CaCl2, 20% w/v PEG 3350 |
