9T6K
Crystal structure of wild-type c-MET bound by glumetinib.
This is a non-PDB format compatible entry.
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | DIAMOND BEAMLINE I04 |
| Synchrotron site | Diamond |
| Beamline | I04 |
| Temperature [K] | 100 |
| Detector technology | PIXEL |
| Collection date | 2025-10-06 |
| Detector | DECTRIS EIGER X 16M |
| Wavelength(s) | 0.95373 |
| Spacegroup name | P 1 21 1 |
| Unit cell lengths | 37.958, 42.719, 85.287 |
| Unit cell angles | 90.00, 92.50, 90.00 |
Refinement procedure
| Resolution | 42.600 - 1.133 |
| R-factor | 0.1827 |
| Rwork | 0.182 |
| R-free | 0.19660 |
| Structure solution method | MOLECULAR REPLACEMENT |
| RMSD bond length | 0.014 |
| RMSD bond angle | 1.270 |
| Data reduction software | autoPROC |
| Data scaling software | autoPROC |
| Phasing software | PHASER |
| Refinement software | BUSTER (2.11.8) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 42.603 | 1.254 |
| High resolution limit [Å] | 1.133 | 1.133 |
| Number of reflections | 71914 | 3596 |
| <I/σ(I)> | 10.9 | |
| Completeness [%] | 85.6 | |
| Redundancy | 3.6 | |
| CC(1/2) | 0.998 | 0.693 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION, SITTING DROP | 293 | 30% PEG400, 0.1 M PCTP pH 8.5 |
