9T1P

Human PI3Kdelta in complex with IOA-288

This is a non-PDB format compatible entry.

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	SLS BEAMLINE X06SA
Synchrotron site	SLS
Beamline	X06SA
Temperature [K]	100
Detector technology	PIXEL
Collection date	2011-02-11
Detector	DECTRIS PILATUS 6M
Wavelength(s)	0.9999
Spacegroup name	P 21 21 21
Unit cell lengths	93.232, 113.339, 144.594
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	48.430 - 2.970
R-factor	0.2204
Rwork	0.219
R-free	0.27550
Structure solution method	MOLECULAR REPLACEMENT
Starting model (for MR)	NONE
RMSD bond length	0.007
RMSD bond angle	0.840
Data reduction software	XDS
Data scaling software	SCALA
Phasing software	PHASER
Refinement software	BUSTER (2.11.8 (17-JUL-2025))

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	50.000	3.200
High resolution limit [Å]	2.970	2.970
Rmeas	0.140	0.650
Number of reflections	32158	5053
<I/σ(I)>	2.3	1.6
Completeness [%]	99.2	98.1
Redundancy	3.7	3.8

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION		293	16% PEG6000, 0.10 M KCL, 0.10 M MES pH 6.0