9T0B
Crystal structure of D1228V c-MET bound by sitravatinib.
This is a non-PDB format compatible entry.
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | SOLEIL BEAMLINE PROXIMA 1 |
| Synchrotron site | SOLEIL |
| Beamline | PROXIMA 1 |
| Temperature [K] | 100 |
| Detector technology | PIXEL |
| Collection date | 2024-10-23 |
| Detector | DECTRIS EIGER X 16M |
| Wavelength(s) | 0.97856 |
| Spacegroup name | P 21 21 21 |
| Unit cell lengths | 40.240, 65.540, 127.450 |
| Unit cell angles | 90.00, 90.00, 90.00 |
Refinement procedure
| Resolution | 63.730 - 1.539 |
| R-factor | 0.2505 |
| Rwork | 0.248 |
| R-free | 0.29420 |
| Structure solution method | MOLECULAR REPLACEMENT |
| RMSD bond length | 0.010 |
| RMSD bond angle | 1.010 |
| Data reduction software | XDS |
| Data scaling software | XDS |
| Phasing software | PHASER |
| Refinement software | BUSTER (2.11.8) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 63.730 | 1.730 |
| High resolution limit [Å] | 1.540 | 1.540 |
| Number of reflections | 34638 | 1732 |
| <I/σ(I)> | 8.5 | |
| Completeness [%] | 91.6 | 63.7 |
| Redundancy | 5.6 | |
| CC(1/2) | 0.995 | 0.372 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION, SITTING DROP | 293 | 25% PEG3350, 0.2 M Na OAc, 0.1 M PCTP pH 6.0 |
