9QX6

Crystal structure of RXR alpha LBD bound to a synthetic agonist FN537 and a coactivator fragment

This is a non-PDB format compatible entry.

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Synchrotron site	PETRA III, EMBL c/o DESY
Beamline	P13 (MX1)
Temperature [K]	100
Detector technology	PIXEL
Collection date	2024-11-29
Detector	DECTRIS EIGER2 X 16M
Wavelength(s)	0.8731
Spacegroup name	P 43 21 2
Unit cell lengths	64.055, 64.055, 111.626
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	32.170 - 1.460
R-factor	0.1832
Rwork	0.182
R-free	0.21300
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.007
RMSD bond angle	0.951
Data reduction software	XDS
Data scaling software	XSCALE
Phasing software	PHASER
Refinement software	PHENIX (1.21.1)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	32.170	1.500
High resolution limit [Å]	1.460	1.460
Rmerge	0.148	0.525
Rmeas	0.151	0.558
Rpim	0.030	0.182
Number of reflections	40702	2598
<I/σ(I)>	15.35	3.96
Completeness [%]	98.9	89.63
Redundancy	21.4	8.7
CC(1/2)	0.995	0.805

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, HANGING DROP		289	20% PEG3350, 0.2M calcium acetate