8PUX

TEAD2 with a covalent inhibitor

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ESRF BEAMLINE BM30A
Synchrotron site	ESRF
Beamline	BM30A
Temperature [K]	100
Detector technology	PIXEL
Collection date	2023-06-10
Detector	DECTRIS PILATUS 6M-F
Wavelength(s)	0.9697
Spacegroup name	C 1 2 1
Unit cell lengths	122.306, 61.613, 79.704
Unit cell angles	90.00, 117.55, 90.00

Refinement procedure

Resolution	54.280 - 2.050
R-factor	0.22152
Rwork	0.220
R-free	0.26051
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.008
RMSD bond angle	1.474
Data reduction software	XDS
Data scaling software	XDS
Phasing software	PHASER
Refinement software	REFMAC (5.8.0267)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	54.280	2.120
High resolution limit [Å]	2.050	2.050
Number of reflections	33152	3290
<I/σ(I)>	11.63
Completeness [%]	99.7
Redundancy	1.9
CC(1/2)	0.999	0.907

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, HANGING DROP		298	2.8M sodium formate