8Z5L
Crystal structure of metallo-beta-lactamse, IMP-1, complexed with a quinolinone-based inhibitor
This is a non-PDB format compatible entry.
Replaces: 8Y0SSummary for 8Z5L
| Entry DOI | 10.2210/pdb8z5l/pdb |
| Descriptor | Metallo-beta-lactamase type 2, ZINC ION, 3-[2-azanyl-5-[2-cyclohexylethyl-[3-(4-methylphenoxy)propyl]amino]phenyl]propanoic acid, ... (4 entities in total) |
| Functional Keywords | beta-lactamase inhibitor, antibiotic, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Serratia marcescens |
| Total number of polymer chains | 4 |
| Total formula weight | 104403.47 |
| Authors | Kamo, T.,Kuroda, K.,Nimura, S.,Guo, Y.,Kondo, S.,Nukaga, M.,Hoshino, T. (deposition date: 2024-04-18, release date: 2024-05-08, Last modification date: 2024-05-15) |
| Primary citation | Kamo, T.,Kuroda, K.,Nimura, S.,Guo, Y.,Kondo, S.,Nukaga, M.,Hoshino, T. Development of Inhibitory Compounds for Metallo-beta-lactamase through Computational Design and Crystallographic Analysis. Biochemistry, 2024 Cited by PubMed: 38690676DOI: 10.1021/acs.biochem.4c00069 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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