8OWG

Crystal structure of D1228V c-MET bound by compound 2

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	DIAMOND BEAMLINE I04
Synchrotron site	Diamond
Beamline	I04
Temperature [K]	100
Detector technology	PIXEL
Collection date	2017-02-20
Detector	DECTRIS PILATUS 6M
Wavelength(s)	0.9795
Spacegroup name	P 21 21 2
Unit cell lengths	254.815, 46.198, 81.064
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	81.060 - 2.631
R-factor	0.283
Rwork	0.281
R-free	0.32920
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.007
RMSD bond angle	0.840
Data reduction software	XDS
Data scaling software	XDS
Phasing software	PHASER
Refinement software	BUSTER (2.11.8 (8-JUN-2022))

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	200.000	2.680
High resolution limit [Å]	2.630	2.630
Number of reflections	29537	1454
<I/σ(I)>	6.7
Completeness [%]	100.0
Redundancy	6.4
CC(1/2)	0.993	0.542

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, SITTING DROP		293	15 % PEG2000 MME, 0.1 M PCPT pH 6.5