8OW3

Crystal structure of wild-type c-MET bound by compound 2

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	SOLEIL BEAMLINE PROXIMA 2
Synchrotron site	SOLEIL
Beamline	PROXIMA 2
Temperature [K]	100
Detector technology	PIXEL
Collection date	2017-04-05
Detector	DECTRIS PILATUS 6M
Wavelength(s)	0.98000
Spacegroup name	C 1 2 1
Unit cell lengths	123.660, 45.610, 53.760
Unit cell angles	90.00, 108.29, 90.00

Refinement procedure

Resolution	46.400 - 2.270
R-factor	0.2471
Rwork	0.244
R-free	0.29530
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.008
RMSD bond angle	0.890
Data reduction software	XDS
Data scaling software	XDS
Phasing software	PHASER
Refinement software	BUSTER (2.11.8 (8-JUN-2022))

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	46.400	2.330
High resolution limit [Å]	2.270	2.270
Number of reflections	13200	899
<I/σ(I)>	6.4
Completeness [%]	98.8
Redundancy	3.4
CC(1/2)	0.994	0.739

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, SITTING DROP		293	12 % PEG3350, 5 % EtOH, 0.2 M Li2SO4, 100 mM PCPT pH 5