7KH8

Human LMPTP in complex with inhibitor

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	SSRL BEAMLINE BL12-2
Synchrotron site	SSRL
Beamline	BL12-2
Temperature [K]	100
Detector technology	PIXEL
Collection date	2017-11-08
Detector	DECTRIS PILATUS3 6M
Wavelength(s)	1.18
Spacegroup name	P 21 21 21
Unit cell lengths	54.971, 58.960, 95.088
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	47.590 - 1.300
R-factor	0.1273
Rwork	0.125
R-free	0.16080
Structure solution method	MOLECULAR REPLACEMENT
Starting model (for MR)	5jnr
RMSD bond length	0.011
RMSD bond angle	1.655
Data reduction software	DENZO
Data scaling software	HKL-2000
Phasing software	PHASER
Refinement software	REFMAC (5.8.0257)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	50.000	1.350
High resolution limit [Å]	1.300	1.300
Rmeas	0.078	0.302
Rpim	0.024	0.134
Number of reflections	72357	4521
<I/σ(I)>	11.3	3.8
Completeness [%]	94.1	59.5
Redundancy	9.5	4.7
CC(1/2)		0.909

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, SITTING DROP	5	293	PEG 3350, Potassium Nitrate, Bis-Tris