7V6Z

Cryo-EM structure of Patched1 (V1084A mutant) in lipid nanodisc, 3.64 angstrom (reprocessed with the dataset of 7dzp)

Replaces:  7DZP

Summary for 7V6Z

• Entry DOI: 10.2210/pdb7v6z/pdb
• EMDB information: 31754
• Descriptor: Protein patched homolog 1,Protein patched homolog 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: caveolae, hedgehog signaling, lipid nanodisc, patched, ptc1 dimer, thermostable mutant., membrane protein
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 1
• Total formula weight: 123084.23

Authors

Luo, Y.,Zhao, Y.,Qu, Q.,Li, D. (deposition date: 2021-08-20, release date: 2021-09-22, Last modification date: 2022-02-16)

• Primary citation: Luo, Y.,Wan, G.,Zhang, X.,Zhou, X.,Wang, Q.,Fan, J.,Cai, H.,Ma, L.,Wu, H.,Qu, Q.,Cong, Y.,Zhao, Y.,Li, D.; Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae.; Structure, 29:1286-, 2021; PubMed: 34174188; DOI: 10.1016/j.str.2021.06.004

Experimental method

ELECTRON MICROSCOPY (3.64 Å)