7B43
Crystal structure of c-MET bound by compound 9
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | SLS BEAMLINE X06SA |
| Synchrotron site | SLS |
| Beamline | X06SA |
| Temperature [K] | 100 |
| Detector technology | PIXEL |
| Collection date | 2020-09-17 |
| Detector | DECTRIS PILATUS 2M |
| Wavelength(s) | 1.00001 |
| Spacegroup name | P 1 |
| Unit cell lengths | 42.867, 59.738, 77.603 |
| Unit cell angles | 76.51, 73.88, 69.25 |
Refinement procedure
| Resolution | 18.410 - 1.870 |
| R-factor | 0.203 |
| Rwork | 0.200 |
| R-free | 0.24800 |
| Structure solution method | MOLECULAR REPLACEMENT |
| Starting model (for MR) | internal |
| RMSD bond length | 0.010 |
| RMSD bond angle | 1.020 |
| Data reduction software | XDS |
| Data scaling software | Aimless |
| Phasing software | PHASER |
| Refinement software | BUSTER (2.11.7) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 73.706 | 2.023 |
| High resolution limit [Å] | 1.870 | 1.873 |
| Rmerge | 0.109 | 0.512 |
| Rmeas | 0.136 | 0.642 |
| Rpim | 0.080 | 0.382 |
| Number of reflections | 28964 | 1449 |
| <I/σ(I)> | 3.8 | |
| Completeness [%] | 70.0 | 34.6 |
| Redundancy | 2.7 | 2.5 |
| CC(1/2) | 0.985 | 0.741 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION, SITTING DROP | 293 | 28 % PEGMME2000, 0.1 M bis-tris pH 6.5 |
