7B3Q
Crystal structure of c-MET bound by compound 1
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | DIAMOND BEAMLINE I04 |
| Synchrotron site | Diamond |
| Beamline | I04 |
| Temperature [K] | 100 |
| Detector technology | PIXEL |
| Collection date | 2017-06-01 |
| Detector | DECTRIS PILATUS3 S 6M |
| Wavelength(s) | 0.979500 |
| Spacegroup name | C 1 2 1 |
| Unit cell lengths | 111.380, 42.590, 85.880 |
| Unit cell angles | 90.00, 120.74, 90.00 |
Refinement procedure
| Resolution | 23.690 - 1.750 |
| R-factor | 0.172 |
| Rwork | 0.171 |
| R-free | 0.19200 |
| Structure solution method | MOLECULAR REPLACEMENT |
| Starting model (for MR) | internal |
| RMSD bond length | 0.010 |
| RMSD bond angle | 0.960 |
| Data reduction software | XDS |
| Data scaling software | SCALA |
| Phasing software | PHASER |
| Refinement software | BUSTER (2.11.6) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 28.630 | 1.850 |
| High resolution limit [Å] | 1.750 | 1.750 |
| Number of reflections | 34142 | 4571 |
| <I/σ(I)> | 32.66 | |
| Completeness [%] | 95.9 | |
| Redundancy | 3 | |
| CC(1/2) | 0.990 | 0.992 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION, SITTING DROP | 293 | 25 % PEG3350, 0.2 M (NH4)2SO4, 0.1 M Na-HEPES pH 7.5 |
