6UYB

Crystal structure of TEAD2 bound to Compound 1

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ALS BEAMLINE 5.0.2
Synchrotron site	ALS
Beamline	5.0.2
Temperature [K]	100
Detector technology	PIXEL
Collection date	2019-08-28
Detector	DECTRIS PILATUS3 6M
Wavelength(s)	0.999
Spacegroup name	C 1 2 1
Unit cell lengths	124.418, 62.090, 79.620
Unit cell angles	90.00, 117.82, 90.00

Refinement procedure

Resolution	70.417 - 1.543
R-factor	0.1976
Rwork	0.196
R-free	0.23190
Structure solution method	MOLECULAR REPLACEMENT
Starting model (for MR)	5emv
Data reduction software	ADDREF
Data scaling software	autoPROC
Phasing software	PHENIX
Refinement software	PHENIX (1.16_3549)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	70.417	1.710
High resolution limit [Å]	1.543	1.543
Number of reflections	39934	1997
<I/σ(I)>	13
Completeness [%]	86.0
Redundancy	3.3
CC(1/2)	0.999	0.609

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, HANGING DROP	6.5	292	200 mM potassium/sodium tartrate pH 6.5 20% PEG 3350