6SDE

Crystal structure of wild-type cMET bound by savolitinib

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	DIAMOND BEAMLINE I04
Synchrotron site	Diamond
Beamline	I04
Temperature [K]	100
Detector technology	PIXEL
Collection date	2017-07-13
Detector	DECTRIS PILATUS3 S 6M
Wavelength(s)	0.98003
Spacegroup name	P 21 21 21
Unit cell lengths	42.130, 43.360, 156.410
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	41.780 - 2.490
R-factor	0.206
Rwork	0.203
R-free	0.27300
Structure solution method	MOLECULAR REPLACEMENT
Starting model (for MR)	2wgj
RMSD bond length	0.010
RMSD bond angle	1.070
Data reduction software	XDS
Data scaling software	XSCALE
Phasing software	PHASER
Refinement software	BUSTER (2.11.6)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	43.360	2.560
High resolution limit [Å]	2.490	2.490
Number of reflections	10493	718
<I/σ(I)>	8.8
Completeness [%]	99.1
Redundancy	6.5
CC(1/2)	0.997	0.427

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, SITTING DROP		293	15 % 2-propanol, 15 % PEG4K, 0.2 M PCPT pH 7.5