6CDY
Crystal structure of TEAD complexed with its inhibitor
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | APS BEAMLINE 19-ID |
| Synchrotron site | APS |
| Beamline | 19-ID |
| Temperature [K] | 100 |
| Detector technology | CCD |
| Collection date | 2015-12-15 |
| Detector | ADSC QUANTUM 315r |
| Wavelength(s) | 0.97929 |
| Spacegroup name | C 1 2 1 |
| Unit cell lengths | 122.464, 61.640, 80.421 |
| Unit cell angles | 90.00, 117.40, 90.00 |
Refinement procedure
| Resolution | 38.851 - 2.320 |
| R-factor | 0.2005 |
| Rwork | 0.198 |
| R-free | 0.25500 |
| Structure solution method | MOLECULAR REPLACEMENT |
| Starting model (for MR) | 3l15 |
| RMSD bond length | 0.003 |
| RMSD bond angle | 0.787 |
| Data reduction software | HKL-3000 |
| Data scaling software | HKL-3000 |
| Phasing software | PHASER |
| Refinement software | PHENIX (1.9_1692) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 40.000 | 2.360 |
| High resolution limit [Å] | 2.320 | 2.320 |
| Number of reflections | 22798 | |
| <I/σ(I)> | 21.1 | |
| Completeness [%] | 98.3 | |
| Redundancy | 4.1 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION, HANGING DROP | 7.2 | 293 | 0.1 M Hepes, pH 7.2, 2.4 M sodium formate. |
